Application of MCUS combined with CYFRA21-1,TAP and SCCA in preoperative staging diagnosis of esophageal cancer
Objective To analyze the application value of mini-probe endoscopic ultrasonography (MCUS)combined with cytokerantin-19-fragment(CYFRA21-1),tumor abnormal ptotein(TAP)and squamous cell carcinoma antigen (SCCA) detection in the preoperative staging diagnosis of esophageal cancer. Methods A total of 137 cases of esophageal cancer patients treated at our hospital from August 2020 to November 2022 were selected as the study subjects. Pathological stage was used as the gold standard to analyze the relationship between MCUS stage and pathological stage. The serum CYFRA21-1,SCCA levels and the TAP positive expression were compared with the pathological features and MCUS stage. Our goal was to determine the diagnostic value of serum CYFRA21-1,SCCA levels,and TAP positive expression combined with MCUS stage in the pathological staging of esophageal cancer. Results The comprehensive accuracy rate of MCUS in diagnosing the pathological stage of esophageal cancer was 88.89％. Serum CYFRA21-1 and SCCA levels were as follows:T3-4>T1-2,low differentiation>high differentiation and medium differentiation,Ⅲ～Ⅳ>Ⅰ～Ⅱ,MCUS stage T4>T3>T1,T2,with statistical significance(P<0.05). There was no significant difference in the positive rate of TAP among different pathological stages,differentiation degree,TNM stage and MCUS stage(P>0.05). Serum CYFRA21-1,SCCA level,TAP positive expression,combined with MCUS examination,the accuracy of pathological staging of esophageal cancer was increased to 95.62％. Conclusion Combining MCUS with serum CYFRA21-1,SCCA levels and TAP detection can accurately diagnose the preoperative staging of esophageal cancer. This comprehensive approach provides a reliable basis for the clinical treatment of esophageal cancer.
万方数据
维普
