The relationship between serum total bilirubin,AST,ALT,ALB levels and the efficacy of blue light therapy in neonatal pathological jaundice
Objective To investigate the relationship between serum total bilirubin ,aspartate aminotransferase(AST),alanine aminotransferase(ALT),albumin(ALB)levels and the efficacy of blue light therapy in newborns with pathological jaundice. Methods The medical records of 97 neonates diagnosed with and treated for pathologic jaundice in the Neonatal Intensive Care Unit of Nanyang Central Hospital from June 2020 to December 2022 were collected retrospectively. The neonates were divided into two groups based on the effectiveness of blue light therapy:an effective group (57 cases) and an ineffective group (40 cases). The jaundice index,serum total bilirubin,AST,ALT and ALB levels were compared between the two groups. The serum levels of bilirubin,AST,ALT and ALB,and their correlation with the effect of blue light therapy were analyzed. Results Before treatment,the icterus index,serum total bilirubin,AST and ALT levels in the effective group were lower than those in the ineffective group ,and the serum ALB level was higher than that in the ineffective group(t=3.346,3.635,2.273,2.167,8.689,P<0.05). Through logistic multivariate analysis,it was determined that changes in total bilirubin,AST and ALT levels are independent risk factors that affect the severity of neonatal pathological jaundice. On the other hand ,changes in ALB levels were found to be an independent protective factor that affects the severity of pathological jaundice in newborns(P<0.05). Spearman correlation analysis revealed that the levels of serum total bilirubin,AST,and ALT before treatment are directly proportional to the severity of the condition. Conversely ,the levels of ALB are inversely proportional to the severity of the condition(P<0.05). Conclusion The lower the levels of serum total bilirubin, AST,ALT in neonatal pathological jaundice before treatment,the higher the ALB levels. This suggests that the milder the condition of the chilc,the more beneficial the effect of blue light treatment will be.
万方数据
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