The Predictive Value of Serum chemerin, Leptin and apoC Ⅲ Levels for Adverse Pregnancy Outcome in Patients with Gestational Diabetes Mellitus
Objective To analyze the predictive value of serum levels of chemerin ,Leptin and apoC Ⅲ on adverse pregnancy outcome of gestational diabetes mellitus patients. Methods One hundred and thirty-one GDM patients admitted to the Third Hospital of Xingtai City from May 2020 to August 2022 were collected(GDM group),and another 126 pregnant women who underwent oral 75g glucose tolerance test in our hospital during the same period were selected(control group).The levels of chemerin,leptin and apoCⅢbetween the GDM group and the control group were compared. Adverse pregnancy outcomes in the two groups were analyzed,including abnormal amniotic fluid,premature delivery,cesarean section,intrauterine distress, and delivery of macrosomia. The levels of chemerin,leptin and apoC Ⅲ in different pregnancy outcomes(divided into normal pregnancy outcomes and adverse pregnancy outcomes)in the GDM group were compared, and multifactor logistic regression was used to analyze the risk factors affecting adverse pregnancy outcomes in GDM. ROC curve was plotted to analyze the predictive value of chemerin ,leptin and apoC Ⅲ combined detection of GDM adverse pregnancy outcomes. Results Serum chemerin,leptin and apoCⅢ levels in GDM group were significantly higher than those in control group,and the difference was statistically significant(P<0.05). The serum levels of chemerin,Leptin and apoC Ⅲ in GDM group were higher than those in normal pregnancy group,and the difference was statistically significant(P<0.05). The results of multivariate Logistic regression showed that the rising levels of chemerin,Leptin and ApoC Ⅲ were the risk factors for GDM adverse pregnancy outcome (P<0.05). Multivariate Logistic regression showed that chemerin , leptin and apoCⅢ levels increased as risk factors for adverse pregnancy outcomes with GDM(P<0.05). The sensitivity and specificity of chemerin,leptin and apoC Ⅲ for GDM adverse pregnancy outcome were 91.29％ and 89.22％,respectively. All the above indicators are higher than the single detection(P<0.05). Conclusion Serum chemerin,leptin and ApoC ⅲ are helpful to predict the risk of adverse pregnancy outcome in GDM patients,and joint monitoring of these factors can improve the predictive value of adverse pregnancy outcome in GDM patients,which can provide basis for early intervention and treatment.
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