首页|血府逐瘀汤对狼疮性肾炎患者胸腺肽β4及Ea-RFC的影响

血府逐瘀汤对狼疮性肾炎患者胸腺肽β4及Ea-RFC的影响

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目的 探讨血府逐瘀汤辅助治疗狼疮性肾炎(LN)的效果及对患者胸腺肽β4及Ea花环细胞(Ea-RFC)形成率的影响.方法 选取河北北方学院附属第二医院2020年1月至2021年6月收治的60例狼疮性肾炎患者,按随机数字表法分为观察组(行血府逐瘀汤联合泼尼松与环磷酰胺治疗)30例与对照组(行泼尼松与环磷酰胺治疗)30例,治疗18个月.观察组治疗后临床效果、中医症状、胸腺肽β4表达、Ea-RFC形成率、肾功能及不良反应.结果 观察组治疗总有效率为96.67%,高于对照组的80.00%,差异有统计学意义(P<0.05).治疗后,观察组纳少腹胀、腰膝酸软、面色不华、口黏口苦等中医症状积分低于对照组,差异有统计学意义(P<0.05).治疗后,观察组红细胞沉降率、血清肌酐及胸腺肽β4表达低于对照组,Ea-RFC形成率高于对照组,差异有统计学意义(P<0.05).治疗后,观察组不良反应发生率与对照组比较差异无统计学意义(P>0.05).结论 血府逐瘀汤辅助治疗LN患者疗效确切,能减少患者体内胸腺肽β4表达,提高Ea-RFC,改善肾功能,安全性较高.
Effects of Xuefu Zhuyu decoction on thymosin β4 and Ea-RFC in patients with lupus nephritis
Objective To investigate the impact of Xuefu Zhuyu decoction on thymosin β4 and erythrocyte-antibody rosette-forming cell(Ea-RFC)formation rate in the treatment of patients with lupus ne-phritis. Methods A total of 60 patients with lupus nephritis admitted to the Second Affiliated Hospital of He-bei North University from January 2020 to June 2021 were selected and divided into two groups:the observa-tion group(Xuefu Zhuyu decoction combined with prednisone and cyclophosphamide,30 cases)and the con-trol group(prednisone and cyclophosphamide,30 cases)based on the random number table method. Both groups underwent an 18-month treatment period. After treatment,the clinical outcomes,Traditional Chinese Medicine(TCM)symptoms,thymosinβ4 expression,Ea-RFC formation rate,renal function and adverse re-actions were monitored and compared between the two groups. Results After treatment,the total effective rate of treatment in the observation group was 96.67%,which was higher than the 80.00%in the control group(P<0.05). Additionally,the scores of TCM symptoms such as poor appetite,abdominal distension,soreness and weakness of waist and knees,pale complexion and sticky and bitter mouth in the observation group were lower than those in the control group(P<0.05)after treatment. Furthermore,after treatment,the erythrocyte sedimentation rate and expressions of serum creatinine and thymosin β4 in the observation group were lower, while the Ea-RFC formation rate was higher compared to the control group(P<0.05). It is important to note that after treatment,there were no statistically significant differences in the incidence rates of adverse reactions between the observation group and the control group (P>0.05). Conclusion Xuefu Zhuyu decoction has been shown have a significant efficacy in treating patients with LN. It can reduce the expression of thymosinβ4 in vivo,increase Ea-RFC and improve renal function,all while maintaining a high level of safety.

Xuefu Zhuyu decoctionLupus nephritisImmune functionThymosin β4Erythrocyte-antibody rosette-forming cell

徐娜、韩梅、封锦慧、孙垚、任占芬、贾军利

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河北北方学院附属第二医院药剂科,河北,张家口 075100

河北北方学院附属第二医院手术室,河北,张家口 075100

河北北方学院附属第一医院风湿免疫科,河北,张家口 075100

河北北方学院附属第二医院肾内科,河北,张家口 075100

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血府逐瘀汤 狼疮性肾炎 免疫功能 胸腺肽β4 Ea花环细胞

张家口市重点研发计划

2121133D

2024

分子诊断与治疗杂志
中山大学

分子诊断与治疗杂志

CSTPCD
影响因子:0.65
ISSN:1674-6929
年,卷(期):2024.16(3)
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