The relationship between peripheral blood PRDX6 and clinical characteristics and frequent acute exacerbation in patients with stable COPD
Objective To investigate the relationship between peripheral blood peroxiredoxin 6 (PRDX6)and clinical characteristics,frequent acute exacerbation in patients with stable chronic obstructive pulmonary disease (COPD). Methods 80 stable COPD patients admitted to our department from January 2021 to December 2022 were selected as the study subjects. They were divided into two groups based on the frequency of acute exacerbation within the past 12 months:the frequent acute exacerbation group(n=42)and the non-frequent acute exacerbation group(n=38). The differences of peripheral blood PRDX6 level and clini-cal indicators between the two groups of patients were compared ,and the logistic regression model was used to analyze the factors influencing frequent acute exacerbation in stable COPD patients. Results The peripheral blood PRDX6 levels,the first second forced expiratory volume(FEV1),FEV1/forced vital capacity(FVC), and FEV1 to predicted percentage(FEV1/pred)of the frequent acute exacerbation group were lower than those in the non-frequent acute exacerbation group(t=14.509,4.302,5.755,4.907,P<0.05). Additionally,the BODE index and COPD assessment test (CAT) score were higher in the frequent acute exacerbation group compared to the non-frequent acute exacerbation group (t=4.391,9.212,P<0.05). The peripheral blood PRDX6 level in stable COPD patients showed a positive correlation with FEV1,FEV1/FVC,FEV1/pred(r=0.341,0.327,0.401,0.294,0.301,0.342),and a negative correlation with the BODE index and CAT score(r=-0.328,-0.394,-0.275,-0.351,P<0.05). Logistic regression analysis revealed that an increased periph-eral blood PRDX6 level was a protective factor for frequent acute exacerbation,while an increased CAT score was a risk factor for frequent acute exacerbation. Conclusion The decreased peripheral blood levels of PRDX6 in stable COPD patients are associated with decreased lung function,worsening clinical symptoms, and frequent acute exacerbations.
万方数据
维普
