Efficacy of sintilimab injection as adjuvant chemotherapy in the treatment of non-small cell lung cancer
Objective To study the effect of sintilimab injection as adjuvant chemotherapy in the treatment of non-small cell lung cancer on serum tumor markers and peripheral blood Th17/Treg. Methods Sixty patients with non-small cell lung cancer were admitted to the No. 2 Department of Oncology at Tian-chang Hospital of Traditional Chinese Medicine from January 2020 to January 2023. They were selected and di-vided into two groups:the control group(30 patients undergoing conventional chemotherapy)and the observa-tion group(30 patients undergoing sintilimab injection as adjuvant chemotherapy)using the random number ta-ble method. The efficacy,serum tumor markers,peripheral blood Th17 and Treg cell levels,and toxicities in the two groups were compared. Results The total effective rate in the observation group was higher than that in the control group,showing a statistically significant difference(t=4.286,P<0.05). Following treatment, the levels of carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),cytokeratin 19 fragment (CYFRA21-1),Th17 and Treg cells in both groups decreased significantly. The levels in the observation group were notably lower than those in the control group,with statistically significant differences(t=6.042, 25.734,7.842,7.216,4.426,P<0.05). The incidence rates of toxicities in the observation group were higher than those in the control group. However,there was no statistically significant difference in the incidence rates of bone marrow suppression,fever,abnormal liver function and diarrhea(t=0.659,0.884,1.832,0.480,P>0.05). The incidence of skin rash in the observation group was significantly higher than that in the control group,indicating a statistically significant difference(t=4.800,P<0.05). Conclusion Sintilimab injection as adjuvant chemotherapy for non-small cell lung cancer is proven to be effective. It can regulate tumor markers and T lymphocyte function,additional research on potential toxicities is necessary.
万方数据
维普
