Clinical efficacy of platelet-rich plasma in the treatment of knee osteoarthritis and its effect on serum ghrelin and HMGB1 levels
Objective To investigate the effect of platelet-rich plasma(PRP)on the level of se-rum ghrelin and high mobility group protein 1(HMGB1)in the treatment of knee osteoarthritis. Methods A total of 106 patients with knee osteoarthritis treated at Zigong First People's Hospital from January 2021 to Jan-uary 2023 were selected as the study subjects. They were divided into two groupos based on treatment meth-ods:the PRP treatment group and the hyaluronic acid treatment group ,each consisting of 53 cases. The study compared the therapeutic effects and serum levels of ghrelin and HMGB1 between the two groups. Results The Knee Injury and Osteoarthritis Questionnaire(KOOS)scores,Lysholm scores and bone mineral density in the PRP group were higher than those in the hyaluronic acid group at 1 and 3 months after treatment,with statistical significance(t=3.235,10.437,5.494,3.863,4.183,10.268,P<0.05). The level of ghrelin in the PRP group was higher than that in the hyaluronic acid group at 1 and 3 months after treatment,and the differ-ence was statistically significant(t=2.065,3.611,P<0.05). HMGB1 level was lower than that in the hyaluron-ic acid group,and the difference was statistically significant(t=2.193,6.146,P<0.05). The Visual Analogue Scale(VAS)score in the PRP group was lower than that in the hyaluronic acid group at 1 and 3 months after treatment,and the SF-36 score in the PRP group was higher than that in the hyaluronic acid group,with statis-tical significance (t=3.119,6.661,2.713,3.550,P<0.05). The incidence of adverse reactions in the PRP group and hyaluronic acid group was 9.43% and 13.21%,respectively,and there was no statistical signifi-cance in the incidence of adverse reactions between the two groups(c2=0.376,P>0.05). Conclusion PRP can increase serum ghrelin levels,decrease HMGB1 levels,improve joint function,relieve pain and enhance the quality of life in patients with knee osteoarthritis.
Platelet-rich plasmaKnee osteoarthritisGhrelinHigh mobility group protein 1