Effects of low-dose aspirin combined with calcium and vitamin E treatment on UPR ,MAP and coagulation indexes of pregnancy-induced hypertension
Objective To analyze the therapeutic effects of low-dose aspirin combined with calci-um and vitamin E in gestational hypertension and its effects on urine protein(UPR),mean arterial pressure (MAP)and coagulation indexes. Methods A total of 122 patients with gestational hypertension who were treated at the Second People's Hospital of Henan Province from July 2017 to July 2022,were selected and di-vided into two groups:the control group(n=60 ,treated with magnesium sulfate treatment)and the study group(n=62 ,treated with low-dose aspirin combined with calcium and vitamin E). The treatment effects ,im-pact on UPR ,MAP and coagulation indexes were compared between the two groups ,and the occurrence of ad-verse reactions was observed. Results The total effective rate in the study group(95.16％)was significantly higher than that in the control group(81.67％),and the difference was statistically significant(P<0.05). Aaf-ter treatment ,the levels of MAP ,UPR ,UA and CysC in the study group were lower than those in the control group ,and the difference was statistically significant(P<0.05). After treatment ,PT ,TT and APTT in the study group were longer than those in the control group ,while FIB was lower than that in the control group , and the difference was statistically significant(P<0.05). There was no significant difference in the adverse re-action rate between the study group(17.74％)and the control group(8.33％)(P>0.05). Conclusion Low-dose aspirin ,when combined with calcium and vitamin E ,is effective in treating gestational hypertension.This treatment can improve patients ' UPR levels and coagulation indicators ,helping to control of blood pres-sure. It is safe and has significant clinical value.
万方数据
维普
