Application of transvaginal color ultrasound combined with serum ADAM12-S,β-HCG and progesterone detection in the diagnosis of ectopic pregnancy
Objective To analyze the effects of transvaginal color Doppler ultrasound combined with serum disintegrin-metalloproteinase 12(ADAM12),human chorionic gonadotropin(β-HCG)and pro-gesterone detection in the diagnosis of ectopic pregnancy(EP). Methods 94 cases of EP patients admitted to the People's Hospital of Anyue County,in Sichuan Province from January 2018 to January 2023 were collect-ed for the EP group. Additionally,90 pregnant women with normal intrauterine pregnancies during the same period were selected for the normal pregnancy group. The results of vaginal color Doppler ultrasound ,AD-AM12-S,β-HCG,and progesterone were compared between the two groups. The consistency of transvaginal color Doppler ultrasound,ADAM12-S,β-HCG,and progesterone with clinical diagnosis results was ana-lyzed,and the effectiveness of both the combination and single detection of these four factors in diagnosing uterine ectopic pregnancy was analyzed. Results The endometrial thickness in the EP group was smaller than that in the normal pregnancy group,and the resistance index value in the EP group was higher than that in the normal pregnancy group ,the difference was statistically significant (P<0.05). The levels of ADAM12-S ,β-HCG,and progesterone in the EP group were lower than those in the normal pregnancy group group,and the difference was statistically significant(P<0.05). The combined diagnosis of transvaginal color Doppler ul-trasound,ADAM12-S,β-HCG,and progesterone showed a high consistency with clinical diagnosis(Kappa value=0.869). The diagnostic sensitivity and specificity of transvaginal color Doppler ultrasound for EP were 85.12％ and 84.44％,respectively. For ADAM12-S diagnostics of EP,the sensitivity and specificity were 77.65％ and 81.11％,respectively. β-HCG diagnostics showed a sensitivity of 71.77％ and a specificity of 75.56％,while progesterone diagnosis of EP had a sensitivity of 74.46％and a specificity of 78.89％. The sensi-tivity and specificity of the combined diagnosis of EP using the four methods were 95.74％and 91.11％,which were higher than those of the four methods used for diagnosis alone. Conclusion The combined detection of vaginal color Doppler ultrasound,serum ADAM12-S,β-HCG,and progesterone can effectively enhance the diagnostic efficiency of EP. This is highly significant for the early diagnosis of ectopic pregnancy.
万方数据
维普
