Effects of different antibiotics combined with CGF on revascularization of young permanent teeth and changes of IL-17,CCL21 and IP-10 levels
Objective To analyze the effects of different antibiotics combined with concentrated growth factor(CGF)on revascularization in young permanent teeth and changes in levels of interleukin-17(IL-17),chemokine ligand 21(CCL21)and interferon-gamma-induced protein 10(IP-10). Methods A total of 270 young patients with pulp necrosis or periapical periodontitis of permanent teeth treated at Cangzhou People's Hospital from January 2021 to June 2022 were selected as the study subjects. All patients were treated with pulp revascularization. Based on the use of different antibiotics ,the patients were divided into three groups:group A(n=90),group B(n=90)and group C(n=90). Group A received triple antibiotic paste,group B re-ceived Vitapex paste,and group C received a combination of calcium hydroxide and tinidazole paste. Within each group,patients were further divided into subgroups based on the type of stent used:A1(n=45),B1(n=45),C1(n=45),A2(n=45),B2(n=45)and C2(n=45). CGF stents were used in subgroups A1,B1 and C1,while blood clot stents were used in subgroups A2,B2 and C2. Patients were followed up for 6 months post-treatment,and the study compared the therapeutic outcomes,tooth discoloration,root canal wall thick-ness,crown-to-root ratio,and levels of IL-17,CCL21 and IP-10 in gingival crevicular fluid among all groups.Results There were significant differences in treatment effectiveness among different groups (c2=9.450, 6.394,P<0.05). There was a significant difference in tooth discoloration rates among the different groups(c2=6.625,6.944,P<0.05). The levels of IL-17,CCL21 and IP-10 in the crevicular fluid of the different groups were compared as follows:Group A1>B1>C1,group A2>B2>C2 (F=13.290,14.842,9.470,12.537, 21.416,6.211,P<0.05). Conclusion The combination of calcium hydroxide and tinidazole paste with CGF has a more positive effect on the revascularization of young permanent teeth and the levels of IL-17,CCL21 and IP-10 in gingival crevicular fluid compared to triple antibiotics and Vitapex paste.
万方数据
维普
