Efficacy and changes in psychological state of patients with somatoform disorders treated with fluoxetine combined with biofeedback
Objective To explore the efficacy of fluoxetine combined with biofeedback therapy in patients with somatoform disorders and the improvement of psychological state. Methods A total of 108 pa-tients with somatic form disorder were admitted to Hengshui Seventh People's Hospital from July 2020 to June 2021 and were selected as the study subjects. They were divided into two groups:the fluoxetine treatment group(fluoxetine treatment,54 cases)and the fluoxetine combined with biofeedback treatment group(54 cas-es)using a random number table method. Additionally,during the same period,108 healthy volunteers were recruited as the control group. The differences in heart rate variability (HRV) among the three groups were compared. The changes in mental state before and after treatment between the fluoxetine treatment group and the fluoxetine combined with biofeedback treatment group were compared ,any occurrences of adverse reac-tions during treatment were recorded. Results After 8 weeks of treatment,the scores of SCL-90,SSS and HAMA in both groups decreased. The scores of SCL-90,SSS and HAMA in the fluoxetine combined with bio-feedback treatment group were lower than those in the fluoxetine treatment group ,with statistical significance (t=2.361,3.859,12.329,P<0.05). HF,LF and LF/HF in both the fluoxetine treatment group and the fluox-etine combined with biofeedback treatment group were lower than those in the control group. HF％ and LF％were higher than those in the control group,with statistical significance (F=331.611,757.501,80.773, 33.151,410.655,P<0.05). After 8 weeks of treatment,the levels of HF,LF,HF％ and LF％ increased and LF/HF decreased in both groups. The HF,LF and LF/HF levels in the fluoxetine combined with biofeedback treatment group were higher than those in the fluoxetine treatment group ,while the HF％and LF％were lower than those in the fluoxetine treatment group. The difference was statistically significant (t=6.417,6.075, 3.917,5.738,2.206,P<0.05). Conclusion Compared to fluoxetine alone,fluoxetine combined with bio-feedback therapy can effectively improve the psychological state of patients with somatoform disorders. It can also regulate the activity of the autonomic nervous system ,leading to better efficacy and safety.
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