Correlation between miR-141-3p and IL-18 and the severity of disease and prognosis in elderly patients with cerebral hemorrhage
Objective To investigate the correlation between miR-141-3p and interleukin-18(IL-18) and the severity and prognosis of senile patients with cerebral hemorrhage. Methods Clinical data from 116 elderly patients with cerebral hemorrhage treated at Chengyang District People's Hospital in Qingdao City from January 2021 to December 2022 were analyzed. The patients were divided into three groups based on disease severity:mild group(n=51),moderate group(n=38)and severe group(n=27). They were followed up for 6 months and categorized into either a good prognosis group(n=79)or a poor prognosis group(n=37). Thirty healthy volunteers were selected as a control group. The levels of miR-141-3p and IL-18 were compared between the control group and the mild ,moderate and severe groups. The correlation between the levels of miR-141-3p and IL-18 and the severity of the disease was analyzed. The prognostic value of miR-141-3p and IL-18 levels in patients was assessed through single and multi-factor analysis. Furthermore,an ROC curve was generated to evaluate the prognostic value of the patients. Results Comparison of miR-141-3p levels:control group >mild group >moderate group >severe group;comparison of IL-18 levels:severe group >moderate group>mild group>control group(F=116.151,77.832,P<0.05). Spearman analysis showed that disease severi-ty was significantly negatively correlated with miR-141-3p(r=-0.668,P<0.05),and positively correlated with IL-18(r=0.583,P<0.05). Compared with the poor prognosis group and the good prognosis group,there were significant differences in age,whether patients were combined with hypertension,diabetes,coronary heart dis-ease,severity of disease,whether patients had ventricular rupture,blood loss,and miR-141-3p and IL-18 levels (t/c2=2.106,5.945,5.988,4.353,19.669,6.707,4.130,7.659,7. 405,P<0.05). The results of multi-factor analysis showed that hypertension,more severe disease,decreased miR-141-3p level and increased IL-18 level were independent risk factors for poor prognosis in elderly patients with cerebral hemorrhage (P<0.05). The ROC curve results showed that the AUC of miR-141-3p,IL-18 and the two combined evaluations were 0.900, 0.825 and 0.960,respectively(P<0.05). Conclusion MiR-141-3p and IL-18 are closely related to the severity and prognosis of elderly patients with cerebral hemorrhage. The combined detection of miR-141-3p and IL-18 shows good efficacy in evaluating the prognosis of elderly patients with cerebral hemorrhage.
万方数据
维普
