Effects of valve replacement combined with coronary artery bypass grafting on serum IL-17,IL-6 and BNP levels in patients with coronary artery disease and valvular disease
Objective To investigate the effect of valve replacement combined with coronary ar-tery bypass grafting on serum interleukin-17 (IL-17),interleukin-8 (IL-6) and brain natriuretic peptide (BNP)levels in patients with coronary artery disease and valve disease. Methods A total of 78 patients with coronary heart disease and valvular disease were admitted to Zhengzhou Seventh People's Hospital from Febru-ary 2021 to January 2022. They were divided into two groups:38 cases in the control group(treated with coro-nary artery bypass grafting)and 40 cases in the experimental group(treated with coronary artery bypass graft-ing+valve replacement),based on the difference in surgical methods. The clinical efficacy ,postoperative re-covery,cardiac function[left ventricular ejection fraction(LVEF),left ventricular end - diastolic diameter (LVEDD),cardiothoracic ratio],inflammatory factors[IL-17,IL-6],heart failure factors[atrial natriuretic peptide (ANP),BNP],and cardiofibrillation factors (CFF) were compared between the two groups. Results The total clinical effectiveness rate of the test group(95.00％)was higher than that of the control group(78.95％),and the difference was statistically significant(P<0.05). There were no significant differenc-es in hospitalization time,ventilator application time and ICU monitoring time between the two groups(P>0.05). Three months postoperatively,the test group had lower LVEDD and cardiothoracic ratio compared tothe control group,while LVEF was higher in the test group,with statistically significant differences(P<0.05). Addi-tionally,levels of IL-6 and IL-17 decreased in both groups after 3 months,with lower levels in the test group than the control group,showing statistical significance(P<0.05). Furthermore,ANP and BNP levels decreased in both groups at 3 months postoperatively,with lower levels in the test group compared to the control group,which was statistically significant(P<0.05). There was no significant difference in the total incidence of adverse events be-tween the two groups(P>0.05). Conclusion Coronary artery bypass grafting+with valve replacement for pa-tients with coronary artery disease and valves issues has shown good clinical efficacy. It can effectively reduce pa-tients' serum levels of IL-6,IL-17,and BNP,improve their cardiac function,and has a certain degree of safety.
Coronary artery disease with valve diseaseValve replacementCoronary artery bypass graftingIL-17IL-6BNP
万方数据
维普
