Analysis of the diagnostic value of three gastric function tests,and combined testing of NLR and CEA for benign and malignant gastric ulcers
Objective To analyze the diagnostic value of three gastric function tests[pepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ),pepsinogen ratio(PGR),neutrophil/lymphocyte ratio(NLR)and carcino-embryonic antigen(CEA)in benign and malignant gastric ulcers. Methods Patients with gastric ulcers admit-ted to Huainan Chaoyang Hospital from January 2020 to November 2022 were selected as the study subjects and referred to as the gastric ulcer group(n=100). Healthy individuals who underwent physical examinations at our hospital during the same period were chosen as the control group(n=60). The levels of PGⅠ,PGⅡPGR, NLR and CEA in the peripheral blood were compared between the two groups. Based on the results of endosco-py and pathological examinations,patients with gastric ulcers were divided into a benign group(n=76)and a malignant group (n=24). The influencing factors of malignant lesions in gastric ulcers were analyzed using multi-factor logistics regression. An ROC curve was drawn to assess the predictive value of peripheral blood PGⅠ, PGⅡ,PGR,NLR and CEA for malignant lesions in gastric ulcers. Results The levels of PG I and PGR in the gastric ulcer group were lower than those in the control group,and the differences were statistically signifi-cant(t=22.044,35.045,P<0.05). The levels of PGⅡ,NLR and CEA in the gastric ulcer group were higher than those in the control group,and the differences were statistically significant(t=17.810,9.481,29.557,P<0.05). Multi-factor logistics regression analysis shows that positive Hp infection(OR=1.865),excessive alcohol consumption(OR=2.046),decreased PG I(OR=2.006),increased PGⅡ(OR=2.028),decreased PGR(OR=2.098),increased NLR(OR=1.958),and increased CEA level(OR=2.071)were independent risk factors for malignant lesions of gastric ulcers (P<0.05). The ROC curve analysis showed that the area under the curve (AUC)of PG I,PGⅡ,PGR,NLR,CEA,and combined detection in predicting benign and malignant lesions in gastric ulcers were 0.822,0.815,0.863,0.786,0.828,0.951,respectively. The combined detection was bet-ter than single detection(P<0.05). Conclusion The combined detection of PGⅠ,PGⅡ,PGR,NLR and CEA has a certain diagnostic value for distinguishing between benign and malignant gastric ulcers.
Gastric ulcerBenign and malignantThree tests of gastric functionNeutrophil/lymphocyte ratioCarcinoembryonic antigen
万方数据
维普
