The role of CTC,RON and c-Met in predicting the prognosis of early triple negative breast cancer
Objective To analyze the effects of circulating tumor cells(CTC),receptor tyrosine kinase(RON)and cellular mesenchymal-epithelial transition factor(c-Met)in predicting the prognosis of early triple negative breast cancer(TNBC). Methods The data from 1225 cases of breast cancer diagnosed and treated at the First Affiliated Hospital of Zhengzhou University from January 2018 to January 2021 were ana-lyzed. The study group was divided into a good prognosis group(n=142)and a poor prognosis group(n=26) based on patient outcomes after treatment. The study aims to compare the expression of CTC between the study group and a healthy group,as well as compare the expression of c-Met and RON between the study group and a control group. Multiple logistic regression analysis will be used to identify independent risk factors affecting the prognosis of TNBC. Additionally,the study will analyze the predictive value of c-Met,RON,and CTC on the prognosis of TNBC patients through the receiver operating characteristic curve (ROC) analysis. Results The CTC level in the research group was higher than that in the healthy group ,and the difference was statisti-cally significant(P<0.05). The positive expression of c-Met and RON in the research group was higher than that in the control group,and the difference was statistically significant(P<0.05). There were 142 cases in the good prognosis group and 26 cases in the poor prognosis group,with no difference in age and tumor diameter between patients with different prognoses(P>0.05). However,there were statistically significant differences in axillary lymph nodes,body mass index,diabetes,RON,c-Met,and CTC between the good prognosis group and the poor prognosis group(P<0.05),An unconditional multivariate logistic regression model analy-sis revealed that axillary lymph node metastasis,CTC positivity,RON positivity,and c-Met positivity were risk factors for the prognosis of TNBC patients(P<0.05). The AUCs of CTC,RON and c-Met alone and the combined detection of all three were 0.764,0.778,0.776,and 0.857,respectively,with the highest AUC ob-served for the combined detection of the three. Conclusion The combined detection of RON,c-MET and CTC levels has a certain predictive value for the prognosis of TNBC patients.
万方数据
维普
