Changes of 5-HT,PGE2 and IL-6 levels in patients with grade Ⅲ mixed hemorrhoids treated with selective hemorrhoidal superior mucosa resection and anastomosis
Objective To analyze the changes in neurotransmitter levels,specifically 5-hydroxy-tryptamine(5-HT),prostaglandin E2(PGE2)and interleukin-6(IL-6),in gradeⅢmixed hemorrhoids treat-ed with selective superior hemorrhoidal mucosal resection and anastomosis(TST). Methods In this study, 108 patients with grade Ⅲ mixed hemorrhoids were retrospectively collected from Dalian Central Hospital be-tween May 2020 and January 2023. They were divided into a control group(n=53,treated with procedure for prolapse and hemorrhoids)and an observation group(n=55,treated with tissue-selecting therapy staple). Clin-ical efficacy,perioperative indicators(operation time,intraoperative blood loss,hospitalization time,postop-erative first defecation time ,postoperative bed time),5-HT ,PGE2 ,inflammatory factors (interleukin-6 , C-reactive protein,tumor necrosis factor-α levels),anorectal dynamic indicators(rectal sensing threshold, anal resting pressure,rectal maximum volume threshold)and complications were compared between the two groups to assess the incidence of symptoms. Results The total effective rate of the observation group(94.55％)was higher than that of the control group(81.13％),and the difference was statistically significant (P<0.05). The first postoperative defecation time,operation time,postoperative bedtime,and hospitalization time in the observation group were shorter than those in the control group ,and the intraoperative blood loss was less than that in the control group,the difference was statistically significant(P<0.05). After treatment, the levels of 5-HT and PGE2 in both groups decreased,with levels in the observation group lower than those in the control group,the difference was statistically significant(P<0.05). Similarly,the levels of IL-6,CRP, and TNF-αin both groups decreased,after treatment,with levels in the observation group lower than those in the control group,the difference was statistically significant(P<0.05). Additionally,RSTV and RMTV in the observation group were higher than those in the control group,while RASP was lower,the difference was sta-tistically significant(P<0.05). The total incidence of complications in the observation group(7.28％)was low-er than that in the control group(20.75％),the difference was statistically significant(P<0.05). Conclusion TST is more effective in treating gradeⅢmixed hemorrhoids. It can significantly improve perioperative index-es in patients with this condition. Levels of inflammatory factors such as 5-HT,PGE2,IL-6,CRP,and TNF-αare reduced,and postoperative complications are decreased. This is beneficial for postoperative recovery.
万方数据
维普
