Expression and prognostic value of TLR4 and NF-κB in hospitalized patients with AD complicated with pulmonary infection
Objective To investigate the expression and prognostic value of toll-like receptor 4 (TLR4)and inhibitory nuclear factor κB(NF-κB)in peripheral blood of hospitalized patients with pulmonary infection in Alzheimer's disease(AD). Methods To investigate the expression and prognostic value of Toll-like receptor 4(TLR4)and inhibition of nuclear factorκB(NF-κB)in the peripheral blood of hospitalized pa-tients with pulmonary infections in Alzheimer's disease(AD),a total of 324 patients with AD hospitalized at Handan First Hospital from October 2020 to September 2022 were selected for the study. They were catego-rized into an uninfected group(214 cases)and an infected group(110 cases)based on the presence of pulmo-nary infection. The levels of TLR4 and NF-κB in the peripheral blood of both groups were compared. Patients with AD who were complicated by pulmonary infections were followed up for 12 months and further divided into a good prognosis group(81 cases)and a poor prognosis group(29 cases)based on their prognosis. Relevant pa-tient data was collected,and the prognostic value of TLR4 and NF-κB in patients with AD complicated by pul-monary infections was verified using ROC curves. Results The levels of TLR4 and NF-κB in the peripheral blood of the infected group were higher than those of the uninfected group,and the differences were statistically significant(t=15.318,10.233,P<0.05). There were significant differences between the poor prognosis group and the good prognosis group in age,duration of AD,smoking history,long-term bed rest,PSI score,PCT, neutrophil,WBC count,TLR4,and NF-κB(c2/t=9.628,8.670,4.116,4.252,8.951,5.921,2.455,4.108, 4.907,5.884,P<0.05);Logistic regression analysis showed that age,smoking history,pneumonia severity in-dex(PSI)score,peripheral blood TLR4,and NF-κB levels were independent factors influencing the prognosis of patients with AD complicated by pulmonary infection(P<0.05). ROC curve results showed that the AUC of TLR4,NF-κB and the combined AUC were 0.828(0.742～0.914),0.819(0.728～ 0.911)and 0.900(0.841～0.959)in peripheral blood,respectively(P<0.05). Conclusion The levels of TLR4 and NF-κB in the peripher-al blood of AD patients are closely associated with pulmonary infections. The levels of TLR4 and NF-κB in the peripheral blood and their combination can predict the prognosis of AD patients with pulmonary infections.
Toll-like receptor 4Inhibition of nuclear factor κBAlzheimer ' s diseaseLung infection
万方数据
维普
