Analysis of the relationship between serum Hcy,NLR,and C-peptide levels in the third trimester and postpartum blood glucose outcomes in patients with gestational diabetes mellitus
Objective To investigate the relationship between serum homocysteine(Hcy),neu-trophil to lymphocyte ratio(NLR),and C-peptide levels in the third trimester of pregnancy and postpartum blood glucose outcomes among patients with gestational diabetes mellitus(GDM). Methods From May 2020 to May 2022,a study was conducted at Beijing Fengtai Hospital on obstetric prenatal care,hospital childbirth, and prenatal diagnosis of late pregnancy(gestational age 28 weeks or more). The study included 109 patients with GDM as the research subjects. These patients were monitored to determine if their blood sugar metabolism returned to normal within 6 weeks postpartum. The patients were dividied into two groups based on their post-partum blood sugarlevels:abnormal group(n=35)and normal group(n=74). Clinical data and laboratory in-dicators were collected and compared between the two groups. Multivariate logistic analysis was used to ana-lyze the correlation between serum Hcy,NLR and C-peptide levels in the third trimester of pregnancy and post-partum blood glucose outcomes in GDM patients. A receiver operating characteristic curve(ROC)was plotted to assess the predictive value of combined detection of serum Hcy,NLR and C-peptide in the third trimester of pregnancy on postpartum blood glucose outcomes in GDM patients. Results The results of the univariate anal-ysis showed statistically significant differences in late pregnancy BMI ,TG ,serum Hcy levels ,NLR ,and C-peptide levels between the two groups of patients(c2/t=19.141,2.545,6.673,3.822,5.862,P<0.05). The multivariable logistic regression analysis revealed that an elevated BMI(greater than or equal to 28 kg/m2)in late pregnancy,increased levels of serum Hcy and NLR as well as C peptide,were all identified as independent risk factors influencing postpartum glucose outcomes in GDM patients(P<0.05). The ROC curve demonstrated that the area under the curve for serum Hcy level was 0.829,for NLR it was 0.709,for C-peptide it was 0.828,and for their combined detection it was 0.886. Conclusion Serum Hcy,NLR and C-peptide levels in the third trimester are closely related to postpartum blood glucose outcomes in patients with GDM. The combined detec-tion of these factors has a high predictive value for postpartum blood glucose outcomes in GDM patients.
Gestational diabetes mellitusHomocysteineC-peptideRatio of neutrophil to lymphocyte count
万方数据
维普
