Differential diagnosis of colorectal cancer and intestinal polyps by combined detection of TT,Alb,CEA and CA19-9
Objective To explore the value of combined detection of thrombin time(TT)and al-bumin(Alb),carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA19-9)in the differential diag-nosis of colorectal cancer and intestinal polyps. Methods 500 patients with colorectal cancer and 500 patients with intestinal polyps diagnosed by pathology at the Affiliated Taian City Central Hospital of Qingdao Universi-ty were retrospectively analyzed from March 2019 to July 2020. Additionally,500 healthy volunteers were in-cluded as the control group during the same period. The expression levels of TT and Alb,CEA,CA19-9 in the three groups were compared,and a receiver operating characteristic(ROC)curve was drawn to evaluate the ef-fectiveness of single and combined detection in diagnosing and differentiating diagnosis of colorectal cancer and intestinal polyps. Results Compared to the healthy group,the levels of TT and Alb in the colorectal cancer group were significantly decreased,while the levels of CEA and CA19-9 were significantly increased;the dif-ference was statistically significant(Z=-11.69,-27.38,-18.32,-10.28,P<0.05). Similarly,compared to the healthy group,the levels of TT and Alb in the intestinal polyposis group were significantly decreased,while the levels of CEA and CA19-9 were significantly increased;the difference was statistically significant(Z=-3.94,-15.95,-6.17,-3.70,P<0.05). Furthermore,when comparing the intestinal polyposis group to the colorectal cancer group,the levels of TT and Alb were significantly decreased in the later,while the levels of CEA and CA19-9 were significantly increased;this difference was statistically significant(Z=-7.82 ,-13.69 ,-13.89 ,-7.07,P<0.05). ROC curve analysis showed that the AUC of TT and Alb,CEA,CA19-9 combined detection for colorectal cancer screening was 0.96,with a sensitivity of 0.870,and a specificity of 0.956. For screening intestinal polyps,the AUC of combined detection was 0.825,with a sensitivity of 0.684,and a specificity of 0.836. The AUC of distinguishing colorectal cancer from intestinal polyps was 0.851,with a sensitivity of 0.772 and a specificity of 0.820. Conclusion The combined detection of TT and Alb,CEA,and CA19-9 has high clinical value in colorectal cancer screening. It better distinguishes colorectal cancer from intestinal polyps , providing a reference for the screening and differential diagnosis of colorectal cancer and intestinal polyps.
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