Relationship between serum HIF-1α,VEGF and myocardial injury in patients with explosive myocarditis
Objective To explore the relationship between serum hypoxia-inducible factor-1α(HIF-1α),vascular endothelial growth factor(VEGF)and myocardial injury in patients with fulminant myo-carditis. Methods A total of 62 patients with fulminant myocarditis were admitted to the First Affiliated Hos-pital of Zhengzhou University and 40 healthy individuals were enrolled as the study group and the control group between June 2017 and October 2022. The levels of serum HIF-1αand VEGF were detected. Based on prognosis,patients in the study group were divided into a death group and a survival group. The levels of se-rum HIF-1α and VEGF,myocardial injury markers,cardiac ultrasound parameters,and length of hospital stay in the two groups were compared. The correlation between serum HIF-1α,VEGF and myocardial injury markers,cardiac ultrasound parameters,and length of hospital stay,as well as the prognostic value of serum HIF-1α,VEGF and myocardial injury markers were analyzed. Results The levels of serum HIF-1α and VEGF in the study group were higher than those in the control group,with statistically significant differences (P<0.05). The levels of serum HIF-1α,VEGF,brain natriuretic peptide(BNP),creatine kinase isoenzyme (CK-MB)and cardiac troponin I(cTnI)in the death group were higher than those in the survival group. Left ventricular ejection fractions (LVEF) and left ventricular end diastolic diameter (LVEDD) were lower than those in the survival group. The length of hospital stay was longer than that in the survival group. The differenc-es were statistically significant(P<0.05). Pearson correlation analysis showed that serum HIF-1α and VEGF were positively correlated with BNP,CK-MB and cTnI(P<0.05). There was no correlation between serum HIF-1α,VEGF levels and LVEF,LVEDD,or length of hospital stay(P>0.05). The receiver operating char-acteristic curves showed that the area under the curve values of serum HIF-1α,VEGF ,BNP ,CK-MB and cTnI for predicting prognosis were 0.708,0.766,0.847,0.852 and 0.864,respectively. Conclusions Serum levels of HIF-1αand VEGF are closely associated with myocardial injury in patients with fulminant myocardi-tis,and can be used to assess prognosis.
万方数据
维普
