Changes of SDF-1 ,HO-1 and MDA levels in patients with diabetic retinopathy and their correlation with IL-6 ,TNF-α and CRP
Objective To analyze the changes of stromal cell derived factor(SDF-1),heme oxy-genase-1(HO-1)and malondialdehyde(MDA)levels in patients with diabetic retinopathy(DR)and their cor-relation with interleukin-6(IL-6),tumor necrosis factor(TNF-α)and C-reactive protein(CRP). Methods A total of 131 patients with DR were admitted to our hospital from May 2020 to January 2023 and were select-ed as the DR Group. Another 100 patients with type 2 diabetes admitted to our hospital during the same period were selected as the non-DR group. The levels of SDF-1 ,HO-1 and MDA were compared between the two groups ,as well as the levels of IL-6 ,TNF-αand CRP. Furthermore ,the levels of SDF-1 ,HO-1 and MDA in patients with different stages of DR were compared. Logistic regression was used to analyze the related factors affecting the occurrence of DR ,and the correlation of SDF-1 ,HO-1 and MDA levels with IL-6 ,TNF-αand CRP in the DR Group was analyzed. Results The levels of SDF-1 and HO-1 in the DR group were lower than those in the non-DR group ,and MDA levels in the DR group were higher than those in the non-DR group(P<0.05). The levels of IL-6 ,TNF-αand CRP in the DR group were higher than those in the non-DR group(P<0.05). SDF-1 and HO-1 levels were observed to be highest in the I-Ⅱ period ,followed by theⅢ-Ⅳperiod , and lowest in the Ⅴ-Ⅵ period. Conversely ,MDA levels were highest in the Ⅴ-Ⅵ period ,followed by theⅢ-Ⅳperiod ,and lowest in theⅠ-Ⅱperiod. These difference was statistically significant(P<0.05). Logistic multivariate analysis showed that female gender ,BMI≥24 km/m2 ,combined hypertension ,hyperlipidemia , IL-6>1.17 mg/mL ,TNF-α>30 ng/L ,CRP>10 ng/mL ,SDF-1>2 ng/mL ,HO-1<125 ng/mL ,and MDA>4.06μmol/mL were all independent risk factors affecting the occurrence of DR(P<0.05). Furthermore ,serum inflammatory factors IL-6 ,TNF-αand CRP showed a negative correlation with SDF-1 and HO-1 ,but a posi-tive correlation with MDA(P<0.05). Conclusion The levels of SDF-1 ,HO-1 ,MDA ,IL-6 ,CRP ,and TNF-αhave a certain relationship with the occurrence and development of DR. The detection of these indica-tors can provide a new way to further explore the pathogenesis and treatment of DR.
万方数据
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