Correlation between polymorphisms of PLA2R1 and HLA genes and TCM syndromes of membranous nephropathy
Objective To explore the correlation between polymorphisms of phospholipase A2 re-ceptor(PLA2R1)and human leukocyte antigen(HLA)genes and Traditional Chinese Medicine(TCM)syn-dromes of membranous nephropathy(MN). Methods A total of 148 patients with MN were admitted to Shiji-azhuang Second Hospital from January 2020 to May 2022 and were enrolled as the research subjects. The distri-bution of TCM syndromes and polymorphisms of PLA2R1 and HLA genes in all patients was statistically ana-lyzed,and the correlation between polymorphisms of PLA2R1 (rs35771982,rs3749117) and HLA-DQA1 rs2187668 genes and TCM syndromes was also analyzed. Results The levels of the G allele at the PLA2R1 rs35771982 locus and the T allele at the PLA2R1 rs3749117 locus in the qi-yin deficiency group and the spleen-kidney yang deficiency group were higher than those in the lung-spleen qi deficiency group and the liver-kid-ney yin deficiency group. These levels were higher in the blood stasis stagnation group and the fluid-dampness internal stagnation group compared to the wind-dampness toxicity accumulation group and the dampness-heat interior retention group. These differences were statistically significant(P<0.05). There was no significant dif-ference in the distribution of genotypes at the HLA-DQA1 rs2187668 locus among MN patients with different deficiency syndromes(P>0.05). However,there was also no significant difference among MN patients with different actual symptoms (P>0.05). Conclusion The polymorphisms of the PLA2R1 gene are correlated with TCM syndromes in patients with MN. Most patients with deficiency symptoms(qi-yin deficiency,spleen-kidney yang deficiency)and actual syndromes(blood stasis stagnation,fluid-dampness internal stagnation) have variations in the PLA2R1 gene (rs35771982、rs3749117). However,the polymorphisms of the HLA-DQA1 gene,specifically rs2187668 are not correlated with TCM syndromes in MN patients.
万方数据
维普
