Changes of serum levels of human epididymal protein 4, thymidine kinase 1 and bifocorticoid kinase 1 in patients with advanced cervical cancer and their relationship with chemotherapy
Objective To analyze the changes in serum human epididymis protein 4(HE4),thy-midine kinase 1(TK1)and doublecortin-like kinase protein 1(DCLK1)in patients with advanced cervical cancer and their relationship with the effect of chemotherapy. Methods The medical records of 215 patients with advanced cervical cancer who received chemotherapy in the hospital from January 2020 to January 2023 were collected retrospectively. The enrolled patients were divided into two groupd based on the effect of chemo-therapy:a good group consisting of 173 patients with complete remission(CR)and partial remission(PR) and a poor group with 42 patients showing stable disease(SD)and progressive disease(PD). Serum levels of HE4,TK1 and DCLK1 in the two groups were compared. The study aimed to analyze the relationship between serum levels of HE4,TK1 and DCLK1 and the effectiveness of chemotherapy in patients with advanced cervi-cal cancer. Results The proportions of clinical stageⅡ,high differentiation,and no lymph node metastasis in the good group were higher than those in the poor group. The maximum tumor diameter ,serum levels of HE4,TK1 and DCLK1 were lower in the good group compasred to the poor group(P<0.05). Logistic multi-variate analysis revealed that the tumor reaching stageⅣ,moderate to low differentiation,lymph node metas-tasis,and elevated levels of serum HE4,TK1,and DCLK1 were independent factors affecting chemotherapy efficacy in patients with advanced cervical cancer(P<0.05). Spearman correlation analysis showed that clini-cal staging,lymph node metastasis,and serum levels of HE4,TK1 and DCLK1 were negatively correlated with chemotherapy effectiveness in patients with advanced cervical cancer ,while differentiation degree was positively correlated with chemotherapy effectiveness(P<0.05). Conclusion The later the clinical stage,the worse the differentiation,the higher the clinical metastasis,and the higher the levels of HE4,TK1,and DCLK1 in patients with advanced cervical cancer,the more unfavorable chemotherapy is for the patient. These indicators have a certain predictive value for their prognosis
Advanced cervical cancerHuman epididymis protein 4Thymidine kinase 1Doublecortin-like kinase protein 1
万方数据
维普
