Correlation between serum levels of vitamin D,IL-6 and IL-8 and bronchopulmonary dysplasia in premature infants
Objective To analyze the correlation between serum levels of vitamin D ,interleukin-6 (IL-6),interleukin-8(IL-8)and bronchopulmonary dysplasia(BPD)in preterm infants in order to find more effective treatment. Methods A total of 216 premature infants(gestational age≤ 35 weeks,length of stay≥28 days)born in the tertiary neonatal intensive care unit at Tangshan Maternal and Child Health Hospital from January 2020 to January 2023 were selected and divided into a BPD group(n=120)and a non-BPD group(n=96)according to the diagnostic criteria for BPD. The study aimed to compare the changes in serum 1,25-dihy-droxyvitamin D3,1,25-(OH)2D3,IL-6,and IL-8 levels on the 1st,7 th,14 th,21st,and 28 th days be-tween the two groups. Additionally,the research examined the changes in serum 1,25-(OH)2D3,IL-6,and IL-8 levels in the BPD group at the time of discharge from the hospital with different degrees of the disease. Further-more,the study analyzed the correlation between serum 1,25-(OH)2D3,IL-6,and IL-8 levels and changes in FiO2 levels. Results Over time,serum 1,25-(OH)2D3 levels in both groups decreased to their lowest value at the 21st day,with levels in the BPD group consistently lower than those in the non-BPD group at all-time points. This difference was statistically significant(P<0.05). Similarly,serum IL-6 and IL-8 levels peaked at the 14th and 21st day in both groups,with levels in the BPD group consistently higher than those in the non-BPD group at all times. This difference was statistically significant(P<0.05). The order of severity for 1,25-(OH)2D3 level was:severe<moderate<mild,IL-6 and IL-8 levels:severe>moderate>mild,the difference was statistically significant(P<0.05). According to Pearson's Correlation results,serum 1,25-(OH)2D3 was negatively correlated with FiO2 levels,and serum IL-6 and IL-8 levels were positively correlated with FiO2 levels(P<0.05). Conclusion Serum levels of vitamin D,IL-6 and IL-8 are associated with the development of BPD in premature infants. Regular monitoring of these levels helps evaluate progression of BPD in preterm infants,and offers crucial insights for the timely identification and treatment of BPD in clinical settings.
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