Association analysis of glucose metabolism during pregnancy in pregnant women with gestational diabetes mellitus with neonatal glucose,renal function and bilirubin metabolism
Objective To analyse the association between glucose metabolic profile during preg-nancy in pregnant women with gestational diabetes mellitus and neonatal glucose ,renal function and bilirubin metabolism. Methods Ninety-five newborns delivered by GDM patients admitted to Xuancheng People's Hos-pital from January 2021 to March 2023 were retrospectively selected for the study,and 100 neonates delivered by healthy mothers in the same period of gestation were selected as the control group. The blood glucose levels at the end of pregnancy were compared among the three groups;the blood glucose,hemoglobin and calcium levels of the three groups were compared when checked into the neonato logy department. Renal function index-es[Blood urea nitrogen(BUN)and Serum Creatinine(SCr)]were compared among the three groups when checked into the neonato logy department. The bilirubin metabolism of the three groups of neonates when checked into the neonato logy department[Total bilirubin(TBil),direct bilirubin(DBil)and Indirect biliru-bin(IBil)]were also compared. Additionally,the correlation between neonatal blood glucose levels,renal function,bilirubin levels and maternal glucose metabolism in GDM were analyzed. Results Among the 95 patients,54 had ideal blood glucose control(ideal blood glucose control group)and 41 had poor blood glu-cose control(poor blood glucose control group). Fasting blood glucose,glycated hemoglobin and 2-hour post-prandial blood glucose in the poor blood glucose control group were higher than those in the control group andideal blood glucose control group. The differences were statistically significant (P<0.05). The blood glucose values and blood calcium levels of newborns at birth were as follows:control group>ideal blood glucose con-trol group>poorly controlled blood glucose control group. Hemoglobin levels were:control group<ideal blood glucose control group<poorly controlled blood glucose control group. Hemoglobin,SCr,TBil and IBil levels were:control group <ideal blood glucose control group <poor blood glucose control group. The differences were statistically significant(P<0.05). The levels of blood glucose and blood calcium in newborns were nega-tively correlated with the blood glucose metabolism of GDM mothers,while the levels of hemoglobin,SCr, TBil and IBil were positively correlated with the blood glucose metabolism of GDM mothers. These differences were statistically significant(P<0.05). Conclusion GDM has a significant impact on fetuses and newborns. It is important to enhance blood glucose control during pregnancy and closely monitor the blood glucose levels,re-nal function and bilirubin metabolism of newborns born to mothers with GDM in order to prevent complications.
Gestational diabetes mellitusGlucose metabolic profile during pregnancyNeonateBlood glucoseRenal functionBilirubin metabolism
万方数据
维普
