Progress in research on the relationship between vaginal flora and HPV infection and cervical lesions
Cervical cancer is a common malignant tumor in women. Persistent infection with high-risk human papillomavirus is a necessary but insufficient condition for the occurrence of precancerous lesions and progression to cervical cancer. Many microorganisms colonize the surface of the female genital tract. The healthy vaginal flora dominated by lactobacillus plays a key role in protecting the human body. With the development of high-throughput sequencing technology,16S rRNA sequencing,metagenomics sequencing and other new molec-ular technologies have achieved accurate analysis of vaginal microbiota. Lactobacillus deficiency,along with an increase in multiple anaerobic bacteria,is widely associated with human papillomavirus infection and cervical le-sions. This paper reviews the correlation between vaginal flora and human papillomavirus infection and cervical lesions. It also summarizes the effects of race,hormone levels,and other factors on vaginal flora as well as the de-tection methods of vaginal flora,providing new ideas for the prevention and treatment of HPV infection and pre-cancerous lesions. Furthermore,it provides a scientific basis for further study on the etiology and pathogenesis of female reproductive tract diseases and lays a foundation for the prevention and treatment of related diseases.
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维普
