Changes in the expression of circFADS2 and circESPL1 in peripheral blood of children with severe pneumonia and clinical their significance
Objective To study the expression and clinical significance of circFADS2 and circESPL1 in the peripheral blood of children with severe pneumonia(SP).Methods The expression levels of circFADS2 and circESPL1 in the peripheral blood of 120 children with Severe Pneumonia(SP group)and 80 healthy children(control group)admitted to the First People's Hospital of Huoqiu County from January 2020 to January 2023 were measured.The children with SP were categorized into the high-risk group(PSI V),medium-risk group(PSI IV),low-risk group(PSIⅠ～Ⅲ),and good prognosis group and poor prognosis group based on a six-month follow-up.A logistic regression model was used to analyze prognostic factors in children with SP,and an ROC curve was used to assess the predictive value of circFADS2 and circESPL1 on the prognosis of SP.Results The expression levels of circFADS2 and circESPL1 in the peripheral blood of the SP group were higher than those of the control group,and the difference was statistically significant(t=10.109,5.181,P<0.05).The expression levels of circFADS2 and circESPL1 in the peripheral blood of SP children with different severity of the disease were as follows:low-risk group<medium-risk group<high-risk group,with statistically significant differences(F=15.831,11.945,P<0.05).The expression levels of circFADS2 and circESPL1 in the peripheral blood of SP children in the poor prognosis group were higher than those in the good prognosis group,and the difference was statistically significant(t=6.073,3.621,P<0.05).Logistic regression analysis showed that heart failure and increased circFADS2 and circESPL1 expression levels in peripheral blood were risk factors for poor prognosis in SP children(P<0.05).ROC curve analysis showed that the sensitivity and specificity of combined detection of circFADS2 and circESPL1 in peripheral blood in predicting the prognosis of SP children were 84.62%and 71.43%,respectively,which were higher than those of single detection(P<0.05).Conclu-sion The expression of circFADS2 and circESPL1 in the peripheral blood of children with SP increases.The combined detection of circFADS2 and circESPL1 can predict the prognosis of SP.
Severe pneumoniaCircular RNAcircFADS2circESPL1Prognosis
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NSTL
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