Evaluation value of MLPR,NLR and RDW in elderly patients with AECOPD complicated with pulmonary embolism
Objective To investigate the value of monocyte/large platelet ratio(MLPR),neutro-phil/lymphocyte ratio(NLR)and red blood cell distribution width(RDW)in the assessment of acute exacerba-tion of chronic obstructive pulmonary disease in elderly patients with AECOPD.Methods A total of 118 elder-ly patients with AECOPD complicated by pulmonary embolism were admitted to the First Hospital of Handan City from January 2020 to December 2022 and were selected as the observation group.They were divided into categories of mild,moderate,severe and extremely severe based on the percentage of FEV1 in the predicted val-ue(FEV1%pred).Additionally,80 elderly patients with AECOPD without pulmonary embolism were selected as the control group.The general clinical data of the two groups were compared to explore the risk factors for el-derly patients with AECOPD complicated by pulmonary embolism.The study aimed to evaluate the diagnostic efficacy of MLPR,NLR and RDW levels in elderly AECOPD patients with pulmonary embolism and their cor-relation with disease severity.Results The duration of the disease,along with MLPR,NLR,RDW,PLR,FIB and D-dimer levels in the observation group were higher compared to those in the control group.These dif-ferences were statistically significant(t=7.409,17.995,10.733,8.724,13.983,7.829,10.596,P<0.05).Lo-gistic analysis showed that disease duration,MLPR,NLR,RDW,PLR,FIB and D-dimer were independent risk factors for elderly AECOPD complicated with pulmonary embolism(P<0.05).The AUC values for ML-PR,NLR and RDW were 0.866,0.835,0.795 and 0.937,respectively,with the AUC values being higher than those of single detection(P<0.05).The levels of MLPR,NLR and RDW in elderly patients with pulmonary em-bolism were categorized as extremely severe,severe,moderate,mild,with statistically significant differences(F=126.998,37.074,34.927,P<0.05).Spearman analysis showed that MLPR,NLR,and RDW were posi-tively correlated with disease severity(r=0.865,0.775,0.661,P<0.05).Conclusion The levels of MLPR,NLR and RDW increased and were positively correlated with the severity of the disease in elderly AECOPD pa-tients with pulmonary embolism.The combined detection of MLPR,NLR and RDW showed good diagnostic ef-ficacy in elderly AECOPD patients with pulmonary embolism.
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