Predictive role of IGFBP-1,PCT combined with CRP detection in premature rupture of membranes complicated by chorioamnionitis
Objective To analyze the predictive value of insulin growth factor binding protein-1(IGFBP-1),procalcitonin(PCT)and C-reactive protein(CRP)in premature rupture of membranes(PROM)complicated with chorioamnionitis(HCA).Methods The clinical data of 128 pregnant women with PROM ad-mitted to the Daxing District People's Hospital of Beijing from January 2020 to January 2023 were collected.This included 37 cases of PROM complicated with HCA(HCA group)and 91 cases of simple PROM(non-HCA group).The clinical data and the levels of IGFBP-1,PCT and CRP were compared between the HCA group and the non-HCA group.Logistic regression analysis was used to analyze the risk factors of PROM complicated with HCA,and the ROC curve was plotted to analyze the predictive effect of IGFBP-1,PCT and CRP on PROM com-plicated with HCA.Results There were no significant differences between the HCA group and the non-HCA group in the terms of history of induced abortion,age,gestational age,gravidity,and fetal position(P>0.05).However,the HCA group did have significantly higher proportions of PROM gestation weeks<35 weeks,PROM latency≥48 hours,and levels of IGFBP-1,PCT,and CRP compared to the non-HCA group,with the difference being statistically significant(P<0.05).When considering the occurrence of HCA as the dependent variable(y=0,1),logistic regression analysis showed that PROM gestational age<35 weeks,PROM latency≥48 h,increased levels of IGFBP-1,PCT,and CRP were independent risk factors for PROM complicated with HCA(P<0.05).Further,ROC results indicated that the sensitivity and specificity of the combined detection of IGFBP-1,PCT and CRP in predicting PROM complicated with HCA were 0.976 and 0.910,respectively.The combined diagnosis of the three biomarkers was significantly more accurate than each one alone(P<0.05).Conclusion The levels of IGFBP-1,PCT,and CRP expression are significantly increased in patients with PROM complicated by HCA.The combined detection of IGFBP-1,PCT,and CRP can improve the prediction of HCA occurrence and provide valuable reference for clinical decision-making.
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