Correlation analysis of miR-92b-5p and HMGB1 with renal function in patients with type 2 diabetic nephropathy
Objective To investigate the correlation between microrNA-92b-5p(miR-92b-5p),serum high mobility group protein B1(HMGB1)and renal function in patients with type 2 diabetic nephropa-thy.Methods Choose between January 2021 and December 2023,henan zhumadian city centre hospital en-docrinology admitted during the period of 212 cases of patients with type 2 diabetic nephropathy as kidney dis-ease group,the selection to the same period of simple type 2 diabetes patients in our hospital 95 cases as type 2 diabetes mellitus group.Renal function related indexes,miR-92b-5p and HMGB1 levels were compared be-tween the two groups.The correlation between serum miR-92b-5,HMGB1 and renal function in patients with type 2 diabetic nephropathy was evaluated by Pearson correlation analysis.Multivariate Logistic regression was used to analyze the risk factors of kidney disease in patients with type 2 diabetes,and receiver operating char-acteristic curve(ROC)was plotted to further evaluate the predictive value of miR-92b-5p and HMGB1 com-bined detection in patients with type 2 diabetes with kidney disease.Results Univariate analysis showed that there were significant differences in the expression levels of BUN,Scr,eGFR,miR-92b-5p and HMGB1 be-tween the two groups.Pearson analysis showed that HMGB1 was positively correlated with BUN and Scr,but negatively correlated with eGFR(r=0.570,0.646,-0.485,P<0.05).miR-92b-5 was negatively correlated with BUN and Scr,but positively correlated with eGFR(r=-0.526,-0.562,0.442,P<0.05).Multivariate Logistic regression analysis further confirmed that insulin injection,increased BUN,Scr and HMGB1 levels,and decreased eGFR and miR-92b-5p levels were independent risk factors for nephropathy in type 2 diabetes patients(P<0.05).ROC curve analysis showed that the areas under the detection curves of miR-92b-5p,HMGB1 and their combined detection were 0.898,0.932 and 0.961(P<0.05).Conclusion The abnormal renal function in patients with type 2 diabetic nephropathy may be related to the decreased expression of miR-92b-5p and the increased expression of HMGB1 in serum.These two indicators can be used as effective predic-tors of type 2 diabetic nephropathy.
Type 2 diabetic nephropathyMicrorna-92b-5pSerum high mobility group protein B1
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