Epidemiological investigation of HPV among 6,221 female cases in Rizhao City
Objective To analyze the epidemiological characteristics of human papillomavirus(HPV)infection among women attending the outpatient clinic at Rizhao Maternal and Child Health Care Hospi-tal in Shandong Province,and provide a theoretical basis for the detection,prevention and treatment strategies for HPV in Rizhao City.Methods A total of 6,221 female cervical bioexfoliated cells from January 2019 to December 2021 at Rizhao Maternal and Child Health Hospital were collected as research samples.These sam-ples were used to detect 28 HPV genotypes,which were then statistically analyzed using PCR-reverse point hy-bridization.Results Among the 6,221 women tested,the detection rate of HPV was 38.74%(2,410/6,221).The average annual growth rate of the number of subjects was 34.69%,and the average annual growth rate of the detection rate was 16.49%.The difference between the HPV detection rate and the month detected was statisti-cally significant(x2=43.125,P<0.001),with the highest detection rate being 47.40%(282/595)in May.Of all HPV infections,73.57%(1,773/2,410)were simple high-risk infections,followed by 23.44%(565/2,410)of simple low-risk infections.The difference in HPV detection rate among women in different age groups was statisti-cally significant(x2=103.116,P<0.001).The top three age groups for HPV infection rates were<21 years old,>60 years old and 21～25 years old.The top four HPV subtypes in the detection rate were all high-risk types,with HR-HPV16,HR-HPV52,HR-HPV58,and HR-HPV53 leading the way.The total detection rate of HR-HPV was 29.66%(1845/6,221),with a the composition ratio of 75.81%(2,285/3,014).The total detection rate of LR-HPV was 10.24%(637/6,221),with the top four subtypes being LR-HPV54,LR-HPV61,LR-HPV81,and LR-HPV42.The detection rate of HR-HPV was statistically significant in the difference between ages(x2=145.737,P<0.001),with the detection rate of HR-HPV16 in the<21 years old age group at 11.59%(8/69)and 4.44%(8/180)in the 56-60 age group.Conclusion The detection rate of HPV in women in the Rizhao area is increasing year by year.May is the most susceptible month,with individuals under 21 years old and over 60 years old being the most susceptible age groups.Single high-risk HPV16 and HPV52 infections are the most common.
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