Analysis and clinical significance of ApoE and SLCO1B1gene polymorphisms
Objective To investigate the distribution of ApoE and SLCO1B1 gene polymorphisms in the Hebei region,and the relationship between these polymorphisms and key markers of lipid levels,and pro-vide a basis for the rational clinical use of statins.Methods 315 patients from the Hebei region who underwent ApoE and SLCO1B1 gene testing at the People's Hospital of Cangzhou City from August 2019 to August 2023 were included in the study.The distribution of ApoE and SLCO1B1 gene polymorphisms,and genotype distribu-tion were then statistically analyzed.Results A total of 6ApoEgenotypes were detected in 315 patients,with the following percentages:E3/E3(66.98%),E3/E4(18.41%),E2/E3(13.02%),E2/E4(0.95%),E4/E4(0.32%)and E2/E2(0.32%).Additionally,6 SLCO1B1 genotypes were identified,in descending order:*1b/*1b(40.63%),*1a/*1b(33.97%),*1b/*15(13.33%),*1a/*1a(7.30%),*1a/*15(4.44%),and*15/*15(0.32%).Statistically significant differences were found when comparing ApoE genotypes and gene phenotypes among dif-ferent gender distributions(x2=11.40,9.11,P<0.05).Similarly,significant differences were observed when com-paring SLCO1B1genotypes and gene phenotypes among different gender distributions(x2=13.05,7.83,P<0.05).Regarding blood lipid levels,the ApoE gene polymorphism showed a correlation with LDL levels(r=0.167,P<0.05),while the SLCO1B1gene phenotype did not exhibit a significant correlation with various blood lipid indica-tors(P>0.05).Conclusion The ApoE and SLCO1B1 gene polymorphisms in the Hebei population are mainly E3 and type Ⅰ normal metabolic genotypes,respectively.There are differences in ApoE and SLCO1B1 genotypes and gene phenotypes among different genders.ApoEgene phenotypes can affect LDL levels.