Significance of p-IRE1,β-catenin and XIAP in clinical diagnosis and prognosis assessment of inverted papilloma of the nasal cavity and sinuses
Objective To explore phosphorylated inositase-1 protein(p-IRE1),β-catenin(Beta-catenin),and X-linked apoptosis inhibitor protein(XIAP)expression in inverted papilloma of the nasal cavity and sinuses(SNIP)and its significance in clinical diagnosis and prognosis evaluation.Methods A total of 102 patients with SNIP admitted to the First People's Hospital of Pingdingshan City from January 2017 to Janu-ary 2022 were selected for the SNIP group.Nasal sinus involutional papilloma tissues were obtained for patho-logical diagnosis.Another group was chosen during the same period at our hospital for septal deviation or con-tralateral inferior turbinate compensatory hypertrophy,who underwent partial excision of the inferior turbinate mucous membrane.The pathology confirmed the normal nasal mucous membrane tissues for this control group.To compare the expression levels of p-IRE1,β-catenin and XIAP in the tissues of both groups,102 SNIP pa-tients were discharged from the hospital and followed up as outpationt for 2-years.The study aimed to compare the prognosis of SNIP patients based on general information and the positive expression of p-IRE1,β-catenin and XIAP.Additionally,a multivariate logistic regression model was used to analyze the risk factors influenc-ing the prognosis of SNIP patients.Results Comparison of the levels of p-IRE1,β-catenin and XIAP expres-sion between the two groups showed statistically significant differences(P<0.05).The positive rates of p-IRE1,β-catenin and XIAP in the SNIP group were higher than those in the control group,with statistically significant differences(P<0.05).According to the follow-up statistics,there were 81 cases in the good progno-sis group and 21 cases in the poor prognosis group.Comparing the gender and age of the two groups,the dif-ference was not statistically significant(P>0.05).However,when comparing the clinical stage of Krouse,the degree of pathological differentiation,and the positive expression of p-IRE1,β-catenin and XIAP in the two groups,the difference was statistically significant(P<0.05).In a multiple logistic regression model,the re-sults showed that Krouse's clinical stage of T3-T4,degree of pathological differentiation with malignant SNIP,and positive expression of p-IRE1,β-catenin,and XIAP were risk factors for poor prognosis in pa-tients with SNIP(P<0.05).Conclusion The levels of p-IRE1,β-catenin and XIAP in SNIP tissues were sig-nificantly higher than those in normal nasal mucosa tissues.By analyzing the positive expression of these indi-cators,it is possible to predict the prognosis of SNIP,which can aid in guiding follow-up treatment.
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