Predictive value of joint detection of N/OFQ,ApoA1 and hs-CRP for SMI in coronary heart disease
Objective To explore the predictive value of joint detection of endogenous nociceptin(N/OFQ),apolipoprotein A1(ApoA1)and hypersensitive C-reactive protein(hs-CRP)for silent myocardial ischemia(SMI)in coronary heart disease(CHD).Methods A total of 156 patients with coronary heart dis-ease who were admitted to the Department of Cardiovascular Medicine at Jintang First People's Hospital from May 2020 to December 2022 were selected.They were divided into two groups based on the presence or absence of SMI:the SMI group(n=65)and the non-SMI group(n=91).The study aimed to analyze the independent risk factors for SMI in patients with CHD and evaluate the predictive value of joint detection of N/OFQ,ApoA1 and hs-CRP for SMI.Additionally,serum levels of N/OFQ,ApoA1 and hs-CRP in patients with different types of SMI were compared.Results There were statistically significant differences in N/OFQ,ApoA1,hs-CRP,HDL-C and LDL-C between the two groups(P<0.05).N/OFQ>6.43 ng/L,ApoA1>120.58 mg/dL,hs-CRP>14.95 mg/L,and LDL-C>5.07 mmol/L were independent risk factors for SMI in patients with CHD(P<0.05),while HDL-C>2.96 mmol/L was a protective factor(P<0.05).The sensitivity,specificity and AUC of the pre-diction model constructed based on N/OFQ,ApoA1 and hs-CRP for predicting SMI were 80.00%,83.52%and 0.850.Serum N/OFQ,ApoA1 and hs-CRP levels in patients with angina pectoris type and asymptomatic SMI were significantly lower than those in patients with myocardial infarction type SMI(P<0.05).Conclusion Monitoring serum levels of N/OFQ,ApoA1 and hs-CRP can not only help predict early SMI in CHD,but also provide an effective basis for evaluating the progression of myocardial ischemia.
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