Relationship between serum hs-CRP、HMGB1、sTREM-1 and therapeutic effect of imipenem in patients with Gram-negative bacterial pulmonary infection
Objective To investigate the relationship between serum high sensitivity C-reactive protein(hs-CRP),high mobility group protein B1(HMGB1)and soluble triggering receptor expressed on hu-man myeloid cells-1(sTREM-1)and the therapeutic effect of imipenem in patients with Gram-negative bacteri-al pulmonary infection.Methods A total of 100 patients with pulmonary infections caused by Gram-negative bacteria were admitted to the People's Hospital of Anhui Province from January 2021 to April 2023 and were se-lected as the subjects of the study.These patients were treated with imipenem for 7 days and were then divided into two groups based on treatment effectiveness:the effective group(n=71)and the ineffective group(n=29).The levels of hs-CRP,HMGB1 and sTREM-1 before and after treatment were compared between the two groups.Multivariate logistic regression was used to analyze the factors that affect the therapeutic effect of imipe-nem in patients with Gram-negative bacterial pulmonary infections.Additionally,an ROC curve was drawn to analyze the predictive value of serum hs-CRP,HMGB1 and sTREM-1 levels before treatment on the therapeutic effect of imipenem in patients with Gram-negative bacterial pulmonary infections.Results The levels of serum hs-CRP,HMGB1 and sTREM-1 in the effective group before treatment were lower than those in the ineffective group,with statistical significance(t=8.125,6.111,5.863,P<0.05).After treatment,the levels of serum hs-CRP,HMGB1 and sTREM-1 in the effective group were also lower than those in the ineffective group,with statis-tically significant differences(t=9.469,11.563,9.607,P<0.05).Multivariate logistic regression analysis showed that the increase of hs-CRP level(OR=1.941),HMGB1 level(OR=2.100)and sTREM-1 level(OR=1.972)be-fore treatment were independent risk factors for the treatment effect of imipenem in patients with Gram-negative bacterial pulmonary infection(P<0.05).Furthermore,ROC curve analysis demonstrated that the levels of serum hs-CRP,HMGB1 and sTREM-1 before treatment had area showing that combined detection was superior to sin-gle detection(P<0.05).Conclusion Serum levels of hs-CRP,HMGB1 and sTREM-1 were found to be closely related to the therapeutic effects of imipenem in patients with Gram-negative bacterial pulmonary infections.
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