Predictive value of combined detection of IL-6,Hcy,and TG/HDL-C in diabetic patients with peripheral neuropathy
Objective To analyze the predictive value of combined detection of interleukin-6(IL-6),homocysteine(Hcy)and triglyceride/high-density lipoprotein cholesterol ratio(TG/HDL-C)for peripheral neuropathy in diabetic patients.Methods A total of 102 diabetic patients admitted to Funan County People's Hospital from January 2020 to June 2023 were selected as the research subjects.The patients with peripheral neu-ropathy were divided into the complication group(n=38),while the patients without peripheral neuropathy were placed in the control group(n=64).Univariate and multivariate logistic regression were used to analyze the influencing factors of peripheral neuropathy in diabetic patients.Additionally,an ROC curve was drawn to analyze the predictive value of IL-6,Hcy and TG/HDL-C in diabetic patients with peripheral neuropathy.Results Univariate analysis showed that the combination of other complications,IL-6,Hcy,TG,and TG/HDL-C levels were influencing factors for peripheral neuropathy in diabetic patients(P<0.05).Multivariate lo-gistic regression analysis revealed that merged other complications(OR=1.872),elevated IL-6 level(OR=2.284),elevated Hcy level(OR=2.100),elevated TG level(OR=2.151),and elevated TG/HDL-C ratio(OR=2.083)were independent risk factors for peripheral neuropathy in diabetic patients(P<0.05).ROC curve analy-sis indicated that the area under the curve(AUC)for IL-6,Hcy,TG/HDL-C and combined detection in evaluat-ing peripheral neuropathy in diabetic patients were 0.856,0.845,0.799 and 0.948,respectively.Moreover,combined detection was found to be superior to single detection(P<0.05).Conclusion IL-6,Hcy and TG/HDL-C are highly expressed in patients with diabetic peripheral neuropathy.This may serve as an additional pre-dictor for evaluating diabetic patients with peripheral neuropathy.
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