Value of WBC,PGE2 and sTERM-1 in predicting urinary sepsis after mPCNL for kidney stones
Objective To investigate the value of white blood cell(WBC),prostaglandin 2(PGE2)and soluble triggering receptor expressed on myeloid cells-1(sTERM-1)in predicting urinary sepsis af-ter minimally invasive percutaneous nephrolithotomy(mPCNL)for kidney stones.Methods The clinical data of 146 patients with kidney stones who underwent mPCNL at Sichuan Province Building Hospital from Decem-ber 2021 to December 2022 were collected.The patients were divided into group A and group B based on wheth-er they developed urinary sepsis after the operation.WBC,PGE2 and sTERM-1 levels were measured within 6 hours after the operation.The value of these measurements in predicting urinary sepsis was analyzed.Results In this study,17 patients(11.64%)developed urinary sepsis after the operation and were defined as group A.The remaining 129 patients were defined as group B.There was no statistically significant difference in baseline data between the groups(P>0.05).WBC,PGE2 and sTERM-1 levels in group A were significantly higher than those in group B(P<0.05).ROC curve analysis showed that the area under the curve(AUC)values for WBC,PGE2,sTERM-1,and their combination for predicting urinary sepsis after mPCNL were 0.792,0.847,0.795,and 0.897,respectively.The sensitivity was 0.863,0.804,0.763,and 0.904,while the specificity was 0.589,0.753,0.753 and 0.890.The AUC and sensitivity of the combined prediction were significantly higher than those of single predictions.Conclusion WBC,PGE2 and sTERM-1 can be used in combination to predict the occurrence of urinary sepsis after mPCNL for kidney stones.Close monitoring of these indicators is recommend-ed after the operation.
NETL
NSTL
万方数据
