Expressions of serum tumor markers,EGFR,NSE,IL-6 and TNF-α in patients with lung cancer and relationship with pathology and prognosis
Objective To study the expressions of serum tumor markers,epidermal growth factor receptor(EGFR),neuron specific enolase(NSE),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in patients with lung cancer and their relationship with pathology and prognosis.Methods Case data from 83 patients with lung cancer in the Department of Medical Oncology of Luoyang Petrochemical Hospital were col-lected from January 2019 to January 2023.These patients were designated as the observation group.46 healthy volunteers who underwent physical examinations at the hospital during the same period were collected as the control group.Serum tumor markers[carbohydrate antigen 125(CA125),human epididymal protein 4(HE4),carcinoembryonic antigen(CEA),and squamous cell carcinoma associated antigen(SCC)],EGFR-mRNA,NSE,IL-6,and TNF-α were compared between the two groups,and the expressions of these indicators in lung cancer patients with different pathological subtypes were compared,and their relationship with prognosis was analyzed.Results The levels of serum CA125,HE4,CEA,SCC,EGFR-mRNA,NSE,IL-6,and TNF-α in the observation group were higher than those in the control group(t=14.276,12.298,15.879,8.352,27.388,5.713,26.582,12.823,P<0.05).The levels of serum CA125 and SCC in lung cancer patients were ranked as follows:squamous cell carcinoma group>adenocarcinoma group>small cell lung cancer group(P<0.05),and serum HE4 level in lung cancer patients was manifested as adenocarcinoma group>squamous cell carcinoma group>small cell lung cancer group(P<0.05),and serum CEA level showed adenocarcinoma group>small cell lung cancer group>squamous cell carcinoma group(P<0.05).A comparison of serum NSE level revealed small cell lung cancer group>adenocarcinoma group>squamous cell carcinoma group(P<0.05).Furthermore,the levels of serum CA125,HE4,CEA,SCC,EGFR-mRNA,NSE,IL-6,and TNF-α were higher in the poor prog-nosis group than those in the good prognosis group(P<0.05).The efficiency of serum NSE in predicting a poor prognosis for lung cancer was found to be the highest.When the cutoff value of serum NSE was greater than 14.15 ng/mL,the area under the curve(AUC)was 0.830.Conclusion Serum tumor markers,such as EGFR-mRNA,NSE,IL-6,and TNF-α are often found to be highly expressed in lung cancer patients.Additionally,tu-mor markers and NSE levels have been shown to be correlated with the pathological subtypes of lung cancer.These indicators can serve as valuable markers for predicting a poor prognosis in individuals with lung cancer.
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