Risk factors for in-stent restenosis after PCI for coronary heart disease and their relationship with vWF,RDW and sICAM-1
Objective To explore the risk factors for in-stent restenosis after percutaneous coro-nary intervention(PCI)in patients with coronary heart disease(CHD)and their relationship with von Wille-brand factor(vWF),red blood cell distribution width(RDW)and soluble intercellular adhesion molecular-1(sICAM-1).Methods 102 patients with coronary heart disease who underwent elective PCI at Tangshan Hon-gci Hospital from June 2020 to June 2022 were selected as the study subjects and followed up by telephone or outpatient for 1 year.Based on the occurrence of in-stent restenosis,the patients were divided into two groups:the stenosis group(31 cases)and the non-stenosis group(71 cases).Multivariate binary logistic regression anal-ysis was conducted to analyze the risk factors of in-stent restenosis after PCI.A receiver operating characteristic(ROC)curve was generated to assess the predictive value of vWF,RDW and sICAM-1 on in-stent restenosis af-ter PCI.Results The prevalence rate of diabetes mellitus,Gensini score,vWF,RDW and sICAM-1 in the ste-nosis group were higher than those in the non-stenosis group,and the differences were statistically significant(P<0.05).The levels of vWF,RDW and sICAM-1 in patients with CHD were positively correlated with Gensi-ni score(r=0.479,0.325,0.450,P<0.05).Multivariate logistic regression analysis showed that diabetes melli-tus and high levels of vWF,RDW and sICAM-1 were independent risk factors for in-stent restenosis after PCI in patients with CHD(P<0.05).The area under the curves(AUCs)of peripheral blood vWF,RDW,and sI-CAM-1 predicting in-stent restenosis in CHD patients after PCI were 0.814,0.760,and 0.771,respectively(P<0.05),and the AUCs were 0.814,0.760 and 0.771 respectively.Conclusion Diabetes mellitus,high levels of vWF,RDW and sICAM-1 are risk factors for in-stent restenosis in patients with CHD after PCI.Monitoring these levels clinically can help guide treatment decisions after PCI to enhance long-term patient prognosis.
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