Relationship between NF-κB,BDNF and NGF in peripheral blood and bortezomib related peripheral neuropathy
Objective To investigate the relationship between nuclear factor κB(NF-κB),brain-derived neurotrophic factor(BDNF)and nerve growth factor(NGF)in peripheral blood and bortezomib asso-ciated peripheral neuropathy(BiPN).Methods 106 patients with multiple myeloma(MM)admitted to the Affiliated Hospital of Chengde Medical College from August 2020 to August 2023 were selected as the study objects,all patients were treated with bortezomib.The relative expression of NF-κB mRNA in peripheral blood and the levels of BDNF,NGF and P75 neuronutrient receptor(P75NTR)in serum were compared before and after treatment.After treatment,patients were divided into PN group(n=49)and no PN group(n=57)accord-ing to the occurrence of PN.Single and multi-factor Logistic regression analysis was conducted to analyze the influencing factors of BiPN in MM patients.The predictive value of NF-κB,BDNF,NGF and P75NTR levels in peripheral blood before treatment in patients with MM treated with bortezomib peripheral neuropathy was an-alyzed by receiver operating characteristic(ROC)curve.Results After treatment,the relative expression of NF-κB mRNA and P75NTR levels were lower than before treatment(t=7.282 and 8.069,P<0.05),and the se-rum BDNF and NGF levels were higher than before treatment(t=13.234 and 7.152,P<0.05).The frequency of administration,the relative expression of NF-κB mRNA before treatment,and the levels of serum P75NTR,BDNF and NGF were compared between the two groups,and the differences were statistically sig-nificant(t=6.552,8.134,8.447,4.852 and 6.607,P<0.05).Dosing twice a week,high NF-κB mRNA expres-sion,increased P75NTR level before treatment,and decreased serum BDNF level and NGF level were inde-pendent risk factors for peripheral neuropathy in MM patients treated with bortezomib(P<0.05).ROC curve analysis showed that the combined prediction of NF-κB mRNA,serum BDNF,NGF and P75NTR levels was higher than that of each index alone(P<0.01).Conclusion The combined detection of NF-κB mRNA,serum BDNF,NGF and P75NTR levels has a certain predictive value for BIPN.
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