The changes of AFP,PLR and ILF3 levels in the assessment of early postoperative recurrence and metastasis of gastric cancer
Objective To investigate the value of alpha-fetoprotein(AFP),platelet-lymphocyte ratio(PLR)and interleukin enhancer binding factor 3(ILF3)in early assessment of postoperative recurrence and metastasis of gastric cancer.Methods Clinical data of 162 patients undergoing radical gastrectomy admit-ted to Anyang Hospital of Traditional Chinese Medicine from April 2018 to April 2021 were retrospectively se-lected.AFP,PLR and ILF3 were detected in all patients before surgery,and the patients were followed up for 2 years after surgery.The patients were divided into normal group(n=94)and metastatic group(n=68)ac-cording to their early recurrence and metastasis.General data and AFP,PLR and ILF3 levels of patients in the two groups were compared.Multivariate logistic regression was used to analyze the factors affecting the early postoperative recurrence and metastasis of patients with gastric cancer,and the predictive value of changes in AFP,PLR and ILF3 levels in the early postoperative recurrence and metastasis of patients with gastric cancer was evaluated by drawing receiver operating characteristic(ROC)curve.Results TNM stage,Borrmann classification,lymphatic vessel invasion,age,tumor diameter,CEA,AFP,PLR and ILF3 levels were com-pared between the two groups,and the differences were statistically significant(x2=52.438,54.035,12.635,t=3.097,2.619,2.667,4.885,4.059,4.226,P<0.05).Multivariate logistic regression analysis showed that TNM stage,Borrmann classification,age,tumor diameter,tumor invasion depth,CEA,AFP,PLR and ILF3 levels were all factors that affected early postoperative recurrence and metastasis in gastric cancer patients(P<0.05).ROC curve results showed that the levels of AFP,PLR,ILF3 and AUC area predicted by the three were 0.725,0.696,0.713 and 0.857,respectively,suggesting that all three had certain prediction value and the combined effect of the three was the best(P<0.05).Conclusion The levels of AFP,PLR and ILF3 in the serum of patients with early postoperative recurrence and metastasis of gastric cancer showed high levels of ex-pression before operation,which has certain application value for the prediction of early postoperative recur-rence and metastasis of gastric cancer.
AFPPLRILF3Gastric cancerEarly postoperative recurrence and metastasis
NETL
NSTL
万方数据
