The value and pathological characteristics of serum CYFRA21-1 and CA125 combined with HPV DNA detection in early screening of cervical cancer
Objective To analyze the value and pathological characters of serum cytokerantin-19-fragment(CYFRA21-1),carbohydrate antigen 125(CA125)combined with HPV DNA detection in the early clinical diagnosis of cervical cancer.Methods 152 patients with cervical cancer admitted to Cangzhou Central Hospital from August 2019 to June 2023 were selected as the observation group.Another 80 normal women who underwent physical examinations in our hospital during the same period were chosen as the control group.The serum levels of CYFRA21-1 and CA125,as well as the detection results of HPV DNA were compared between the two groups.Furthermore,the different surgical pathological results,the expression levels of serum CY-FRA21-1 and CA125,and the detection results of HPV DNA were compared within the observation group.Path-ological examination served as the gold standard,and the consistency of serum CYFRA21-1,CA125 levels,HPV DNA detection,and combined detection in the diagnosis of cervical cancer were analyzed.Finally,ROC curves were used to analyze the value of serum CYFRA21-1,CA125 combined with HPV DNA detection for di-agnosing cervical cancer.Results Among the 152 patients,104 cases of squamous cell carcinoma and 48 cas-es of adenocarcinoma were found;There were 66 cases of mild dysplasia,57 cases of moderate dysplasia and 29 cases of severe dysplasia.Among the 152 cases,121 cases(80.13%)were positive for HPV DNA,of which 53 cases(43.80%)were positive for HPV16,39 cases(32.23%)were positive for HPV18 and 88 cases(72.73%)were positive for other 12 samples.The serum CYFRA21-1,CA125 levels and HPV DNA positive rate in the observation group were higher than those in the control group(P<0.05).Serum CYFRA21-1 and CA125 levels:squamous cell carcinoma<adenocarcinoma,mild atypical hyperplasia<moderate atypical hyper-plasia<severe atypical hyperplasia,the differences were statistically significant(P<0.05).There was no signifi-cant difference in the HPV DNA positive rate between the observation group and different stages and types of tu-mor hyperplasia(P>0.05).The consistency Kappa values for serum CYFRA21-1,CA125 levels,and HPV DNA detection alone and combined in the diagnosis of cervical cancer and pathological examination results were 0.677,0.731,0.756,and 0.902 respectively.The AUC of the combined detection of CA125+CYFRA21-1+HPV DNA was 0.894,which was higher than the separate detection of CA125,CYFRA21-1,and HPV DNA(P>0.05).Conclusion The diagnostic efficiency of serum CYFRA21-1,CA125 combined with HPV DNA de-tection is higher than that of single detection.This suggests that the combined detection of three indicators can sig-nificantly improve the diagnostic value of early screening for cervical cancer.This is not only beneficial for cervi-cal cancer disease control,but also provides valuable information for the formulation of clinical treatment plans.
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