Clinical significance of serum cTnI,CK-MB and Mb in patients with acute myocardial infarction after coronary stent intervention
Objective To analyze the changes and clinical significance of serum Cardiac troponin I(cTnI),creatine kinase-MB(CK-MB)and myoglobin(Mb)levels in patients with acute myocardial infarction(AMI).Methods 135 patients with AMI admitted to Beijing Millennium Temple Hospital affiliated with Capi-tal Medical University from April 2020 to June 2023(observation group)were selected as the study subjects.Additionally,100 healthy people who underwent physical examinations during the same period were chosen as the control group.The levels of serum cTnI,CK-MB and Mb were compared between the control group and ob-servation group before and after the operation.The single factors that affect the success of PCI in AMI patients were analyzed.Multiple logistic regression was used to analyze the risk factors affecting the success of PCI sur-gery in AMI patients.The relationship between the PCI success rate and serum cTnI,CK-MB and Mb levels in AMI patients was analyzed using Pearson's correlation.Results The levels of serum cTnI,CK-MB and Mb in the control group were lower than those in the observation group,the levels of serum cTnI,CK-MB and Mb in the observation group before surgery were lower than after surgery,with a statistically significant difference(P<0.05).Following imaging examination,112 patients were successfully operated on(82.96%),while 23 patients were unsuccessful(17.04%).The levels of serum cTnI,CK-MB and Mb in the observation group before opera-tion were higher than after operation,and the differences were statistically significant(P<0.05).There were no significant differences in age,sex,heart function,history of hypertension,diabetes,angina pectoris,and PCI time between the two groups(P>0.05).Comparisons between the two groups included the time from onset to admission,time from onset to PCI,and serum cTnI,CK-MB and Mb levels,all of which showed statistically significant differences(P<0.05).Multiple logistic regression analysis revealed that a time from onset to admis-sion>3 h,time from onset to PCI≥6h,cTnI≥0.04 ng/mL,CK-MB>5 ng/mL,and Mb>50 μg/L were risk factors affecting the success of PCI surgery in AMI patients(P<0.05).Pearson correlation analysis indicated that cTnI,CK-MB and Mb levels were negatively correlated with the success rate of PCI surgery in AMI pa-tients(P<0.05).Conclusion The changes in serum cTnI,CK-MB and Mb levels in AMI patients before and after undergoing PCI can indicate the efficacy of PCI treatment and help predict patient prognosis.This holds sig-nificant clinical importance.
NETL
NSTL
万方数据
