The expression of serum CKMB,ALP and AST and their clinical significance in neonates with hyperbilirubinemia
Objective To investigate alkaline phosphatase(ALP),creatine kinase isoenzyme(CKMB),and aspartate transaminase(AST)in serum,and the level expression of AST and its clinical signifi-cance in neonates with hyperbilirubinemia.Methods A total of 162 neonates with hyperbilirubinemia who were hospitalized at Xinhua Hospital,Shanghai Jiao Tong University School of Medicine from January 2021 to January 2023 were selected as the observation group.Total bilirubin(STB)levels were detected using a transcu-taneous jaundice tester and divided as follows:79 cases in the mild group,64 cases in the moderate group and 19 cases in the severe group.In addition,159 healthy newborns with normal jaundice values(STB<221 μmol/L)were selected as the control group.The levels of CKMB,ALP and AST before and after treatment were com-pared between the control group and the observation group.The levels of CKMB,ALP and AST were compared in the observation group with different STB degrees.The levels of CKMB,ALP and AST in the observation group were compared before and after treatment.Pearson correlation was used to analyze the relationship be-tween CKMB,ALP and AST levels and STB levels.Results Comparison of CKMB,ALP and AST levels:the observation group(after treatment)>the observation group(before treatment)>the control group,the differ-ence was statistically significant(P<0.05).The levels of CKMB,ALP and AST in patients with different STB degrees were compared:mild group<moderate group<severe group,the difference was statistically significant(P<0.05).The levels of CKMB,ALP and AST in the observation group were higher before treatment com-pared to after treatment,and the differences were statistically significant(P<0.05).Pearson correlation analysis indicated that CKMB,ALP and AST levels were positively correlated with STB level(P<0.05).Conclusion Serum CKMB,ALP and AST levels are closely related to the severity of neonatal hyperbilirubinemia,Tri-level variation can be used as a sensitive indicator to evaluate the early diagnosis of neonatal hyperbilirubinemia.
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