Effects of Ginkgo biloba extract on TGF-β1 and HGF levels in children with diabetic nephropathy
Objective To investigate the effects of Ginkgo biloba extract on TGF-β1 and HGF lev-els in children with diabetic nephropathy.Methods A total of 188 diabetic children with kidney injury who re-ceived treatment at Shijiazhuang Sixth Hospital from January 2020 to February 2023 were retrospectively select-ed.They were divided into two groups:the conventional group(82 cases,treated with conventional Western medicine)and the study group(106 cases,treated with ginkgo biloba extract+conventional treatment).The clinical efficacy of the two groups was compared.The differences in renal function related indexes,levels of transforming growth factor-β1(TGF-β1),hepatocyte growth factor(HGF),and the occurrence of adverse re-actions before and after treatment were also compared.Results The total effective rate of the study group was 92.45%,which was higher than that of the conventional group at 81.71%.This difference was statistically signif-icant(x2=4.972,P<0.05).After treatment,renal function indexes such as blood creatinine(Scr),urea nitrogen(BUN),urinary albumin excretion rate(UAER),24 h urinary protein quantity(24hUP)and serum TGF-β1 level decreased in both groups compared to before treatment.Additionally,serum HGF level increased.The changes in these indexes in the study group were greater in the study group than in the conventional group,with statistically significant differences(t=6.024,7.317,11.651,5.486,8.863,10.345,P<0.05).There was no sig-nificant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Gink-go biloba extract is beneficial in treating children with diabetic nephropathy.It can significantly improve renal function and clinical efficacy by adjusting TGF-β1 and HGF levels in patients.
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