Relationship between the expression levels of LN,CHE and TRF in cirrhotic liver cirrhosis and disease in chronic hepatitis B
Objective To explore the relationship between the expression levels of LN,CHE,and TRF and the severity of liver cirrhosis in patients with chronic hepatitis B(CHB),and to provide new insights for clinical diagnosis and treatment.Methods 168 patients with CHB cirrhosis admitted to Zhumadian Central Hospital from February 2021 to December 2022 were selected for the study(CHBC group),and 152 patients with CHB without combined cirrhosis in the same period(CHB group)and 161 people in the population with health checkups(control group)were also selected.The purpose of the study was to compare the levels of LN,CHE,TRF,HA,IV-C and PCⅢin the three groups,and to analyze the correlation between the levels of LN,CHE and TRF and liver fibrosis indexes in the CHBC group,and the efficacy of LN,CHE and TRF alone and in combined assays in assessing liver fibrosis in CHBC patients by using ROC curves.Results The levels of LN,HA,Ⅳ-C and PⅢP in the CHBC group were higher than those in the control group and the CHB group,while the levels of CHE and TRF were lower than those in the control group and the CHB group,showing statis-tically significant differences(P<0.05).The levels of LN,HA,Ⅳ-C and PⅢP in the severe cirrhosis group were higher than those in the mild cirrhosis group and the moderate cirrhosis group,and the levels of CHE and TRF in the CHBC group were lower than those in the mild cirrhosis group and moderate cirrhosis group,and the difference was statistically significant(P<0.05).According to Pearson's analysis,there was a positive correla-tion between the LN level and the levels of HA,Ⅳ-C,and PCⅢ,and a negative correlation between the levels of CHE and TRF and the levels of HA,Ⅳ-C,and PCⅢ(P<0.05).The ROC curves showed that the AUC of the combined detection of liver fibrosis in patients with cirrhosis of CHB by LN,CHE,and TRF was 0.902,which was higher than that of the three individually(0.742,0.837,and 0.739).Conclusion The expression levels of LN,CHE,and TRF are closely related to liver fibrosis in patients with CHBC.The combined detection of LN,CHE,and TRF has a good evaluative value for liver fibrosis in patients with CHBC,and plays a certain guiding role in the clinical evaluation of CHBC.
Chronic hepatitis B cirrhosisLamininCholinesteraseTransferrin
NETL
NSTL
万方数据
