The value of transvaginal ultrasound combined with serum CA125 and CEA detection in differentiating between ovarian cystadenoma and cystadenocarcinoma
Objective To explore the application value of transvaginal ultrasound combined with serum carbohydrate antigen 125(CA125)and carcinoembryonic antigen(CEA)detection in the differential di-agnosis between ovarian cystadenoma and cystadenocarcinoma.Methods The clinical data of 161 patients with ovarian diseases at Maanshan People's Hospital were selected between November 2019 and March 2022.This included 130 cases of cystadenoma and 31 cases of cystadenocarcinoma.All patients underwent transvagi-nal ultrasound examination,as well as serum CA125 and CEA detection.The mass diameter,shape,boundary,internal solid tissue echo,blood flow resistance index(RI)and pulsatility index(PI)were observed by using vaginal ultrasound.The sensitivity,specificity,and area under the ROC curve(AUC)for diagnosing ovarian cystadenoma and cystadenocarcinoma were analyzed using transvaginal ultrasound combined with serum CA125 and CEA detection.Results The PI and RI in the cystadenoma group were higher than those in the cystadeno-carcinoma group(P<0.05).The tumor diameter in the cystadenoma group was larger than that in the cystadeno-carcinoma group.The proportions of regular tumor shape and clear boundary were lower compared to those in the cystadenocarcinoma group,while the proportions of solid internal tumor echo,inner wall papilla and ascites were higher than those in the cystadenocarcinoma group(P<0.05).The levels of CA125 and CEA were higher in the cystadenoma group compared to the cystadenocarcinoma group(P<0.05).The sensitivities of transvagi-nal ultrasound,serum CA125 detection,CEA detection and the combination of the three in differentiating ovari-an cystadenoma from cystadenocarcinoma were 0.839,0.807,0.772 and 0.936,respectively.The specificities were 0.808,0.685,0.654 and 0.939,and the AUCs were 0.839,0.790,0.742 and 0.973 respectively.The sensi-tivity,specificity and AUC of transvaginal ultrasound combined with serum CA125 and CEA detection in the differential diagnosis of ovarian cystadenoma and cystadenocarcinoma were higher than those of a single exami-nation(P<0.05).Conclusion High levels of CA125 and CEA along with low levels of PI and RI can serve as the basis for diagnosing ovarian cancer.Combining transvaginal ultrasound with serum CA125 and CEA detec-tion can improve the efficiency of differential diagnosis between ovarian cystadenoma and cystadenocarcinoma.
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