The value of combined detection of peripheral blood TLR4 mRNA,IL-22,and NLR in assessing the prognosis of patients with sepsis
Objective To evaluate the prognostic value of toll-like receptor 4(TLR4)mRNA,inter-leukin-22(IL-22)and neutrophil/lymphocyte ratio(NLR)combined detection in peripheral blood in patients with sepsis.Methods A total of 108 patients with sepsis who were treated at the First Affiliated Hospital of Hainan Medical College from January 2020 to January 2023 were selected for this study.Based on the patients'prognosis within one month of admission,they were divided into two groups:a good prognosis group(71 cases)and a poor prognosis group(37 cases).Basic data,including gender,age,body mass index(BMI),infection upon admis-sion,history of diabetes,hypertension,cardiovascular disease,use of blood products,mechanical ventilation,multiple organ failure,and laboratory indicators TLR4 mRNA,IL-22,and NLR were collected at enrollment.Uni-variate and multivariate logistic regression analyses were conducted to identify the risk factors influencing the poor prognosis of sepsis.Receiver operating characteristic(ROC)curve was drawn to analyze the efficacy of sin-gle and combined TLR4 mRNA,IL-22,and NLR for evaluating the prognosis of patients with sepsis.Results There were significant differences in age,history of hypertension,cardiovascular disease,mechanical ventilation and multiple organ failure between the good prognosis group and the poor prognosis group(x2=4.427,5.698,4.618,6.948,7.300,P<0.05).The levels of TLR4 mRNA,IL-22 and NLR in the poor prognosis group were high-er than those in the good prognosis group(t=7.649,4.205,8.243,P<0.05).Multivariate logistic regression analy-sis showed that mechanical ventilation,multiple organ failure,TLR4 mRNA,IL-22 and NLR levels were indepen-dent risk factors for poor prognosis in sepsis patients(P<0.05).ROC results show that,the area under the curve(AUC)of TLR4 mRNA,IL-22,and NLR were 0.846,0.747,0.669,and 0.914,respectively.Combined detec-tion was superior to single detection(P<0.05).Conclusion TLR4 mRNA,IL-22 and NLR are related to the prog-nosis of sepsis patients,and all three have good predictive efficacy for the prognosis of patients.
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