The diagnostic value of color Doppler ultrasonography combined with CEA,AFU,and AFP detection in hepatic malignant tumors
Objective To analyze the diagnostic value of color Doppler ultrasonography(CDFI)combined with CEA,α-L-fucosidase(AFU)and alpha-fetoprotein(AFP)in hepatic malignant tumors.Meth-ods A total of 141 patients with liver malignant tumors admitted to Chengyang District People's Hospital of Qingdao from May 2021 to August 2023 were selected for the liver malignant tumor group),and 138 patients with clinically confirmed benign liver disease admitted to our hospital during the same period were selected for the benign liver disease group,and 133 healthy physical examination subjects were selected for the healthy phys-ical examination group.Based on pathological diagnosis,the diagnostic results of CDFI on hepatic malignant tu-mors were analyzed.The levels of RI,Vmax,CEA,AFU and AFP were compared in different groups The diag-nostic results of CDFI for hepatic malignant tumors were analyzed based on pathological diagnosis.The levels of RI,Vmax,CEA,AFU and AFP were compared among different groups and disease types.The consistency of CDFI,CEA,AFU,AFP and pathologic diagnosis was evaluated using the Kappa consistency test.Additional-ly,the diagnostic value of CDFI,CEA,AFU,and AFP in the single and combined detection of liver malignant tumors was analyzed using ROC curve analysis.Results Based on the pathological diagnosis,CDFI detected a total of 118 cases(83.68%)of liver malignancies,including 73 cases of primary liver cancer and 45 cases of secondary liver cancer.Both types of liver cancer were mainly characterized by low blood supply.The levels of RI,Vmax,CEA,AFU and AFP were as follows:the liver cancer group>benign liver disease group>healthy physical examination group,with statistically significant differences(P<0.05).The levels of RI,Vmax,CEA,AFU,and AFP in primary liver cancer were statistically higher than those in secondary liver cancer(P<0.05).The Kappa value of CDFI,CEA,AFU,and AFP combined with pathological diagnosis was 0.766.The sensitiv-ity,specificity,and AUC(95%CI)were 92.55%,91.18%and 0.762(0.637～0.814),respectively.When com-pared to CDFI,CEA,AFU,and AFP,the Kappa value,sensitivity,specificity,and AUC(95%CI)were mea-sured,and the difference was statistically significant(P<0.05).Conclusion Detection of CDFI,CEA,AFU,and AFP levels is valuable in diagnosing liver malignant tumors.Combining these indicators play a complemen-tary role in accurately diagnosing liver malignant tumors.This comprehensive approach improves the reliability of diagnosing liver malignant tumors.
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