Effects of intracoronary prourokinase thrombolysis combined with emergency PCI treatment on the levels of CK-MB,cTnI,and BNP in patients with STEMI
Objective To analyze the effects of intracoronary prourokinase thrombolysis combined with emergency percutaneous coronary intervention(PCI)treatment on creatine kinase isoenzyme(CK-MB),cardiac troponin I(cTnI),and B-type natriuretic peptide(BNP)levels in patients with ST-segment elevation myocardial infarction(STEMI).Methods A total of 195 STEMI patients admitted to the First People's Hospital of Mengcheng County,Anhui Province from July 2019 to December 2022 were selected and divided into a control group(85 cases)receiving PCI and an observation group(110 cases)receiving prourokinase thrombolytic+PCI.After treatment,the clinical efficacy,serum CK-MB,cTnI,and BNP levels,myocardial perfusion grade of TIMI,cardiac function index levels and the occurrence of cardiovascular adverse events were recorded in both groups.Results The total curative effect rate in the observation group was higher than that in the control group,with a statistically significant difference(P<0.05).The serum BNP,cTnI,and CK-MB levels in the observation group were significantly lower than those in the control group,with a statistically significant difference(P<0.05).The proportion of grade 3 TIMI myocardial perfusion in the observation group was significantly higher than that in the control group,with a statistically significant difference(P<0.05).The levels of LVEDV and LVESV in the observation group were significantly lower than those in the control group.The level of LVEF in the observation group was higher than that in the control group,and the difference was significant Statistically significant(P<0.05).The total incidence of clinical cardiovascular adverse events in the observation group was 4.52%,which was lower than that in the control group,with a statistically significant difference(P<0.05).Conclusion Emergency PCI combined with prourokinase thrombolytic therapy for STEMI patients has shown good clinical efficacy.It can effectively improve cardiac function and reduce myocardial damage,increase myocardial perfusion,and decrease the risk of cardiovascular adverse events.This treatment approach has a certain degree of safety.
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